Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy?

被引:70
作者
Depfenhart, Markus [1 ,2 ]
de Villiers, Danielle [3 ]
Lemperle, Gottfried [4 ]
Meyer, Markus [5 ]
Di Somma, Salvatore [6 ,7 ]
机构
[1] Venlo Univ BV, Fac Med, Venlo, Netherlands
[2] Med One Clin Hamburg, Hamburg, Germany
[3] Medika SA, Res & Dev, Pretoria, South Africa
[4] Univ Calif San Diego, Div Plast Surg, San Diego, CA 92103 USA
[5] Univ Indonesia, Fac Med, Jakarta, Indonesia
[6] Univ Rome Sapienza, Dept Med Surg Sci & Translat Med, Rome, Italy
[7] GREAT Network Italy, Rome, Italy
关键词
SARS-CoV-2; COVID-19; Prophylactic; Treatment; Bromhexine; Protease inhibitor; RESPIRATORY SYNDROME CORONAVIRUS; ANTIVIRAL ACTIVITY; IN-VITRO; CHLOROQUINE; SPIKE; INFLUENZA; INFECTION; ACE2; IDENTIFICATION; INHIBITION;
D O I
10.1007/s11739-020-02383-3
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Of huge importance now is to provide a fast, cost-effective, safe, and immediately available pharmaceutical solution to curb the rapid global spread of SARS-CoV-2. Recent publications on SARS-CoV-2 have brought attention to the possible benefit of chloroquine in the treatment of patients infected by SARS-CoV-2. Whether chloroquine can treat SARS-CoV-2 alone and also work as a prophylactic is doubtful. An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE2-binding inhibitor. Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2. We propose the use of bromhexine as a prophylactic and treatment. We encourage the scientific community to assess bromhexine clinically as a prophylactic and curative treatment. If proven to be effective, this would allow a rapid, accessible, and cost-effective application worldwide.
引用
收藏
页码:801 / 812
页数:12
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