Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity

被引：45

作者：

Cavalli, Giacomo ^{[1
]}

机构：

[1] CNRS, Inst Human Genet, F-34396 Montpellier, France

来源：

DEVELOPMENT | 2006年 / 133卷 / 11期

关键词：

D O I：

10.1242/dev.02402

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The epigenetic regulation of chromatin structure and composition has often been studied molecularly in the context of specific DNA-dependent processes. However, epigenetics also play important global roles in shaping and maintaining cell identity, and in patterning the body plan during normal development. Moreover, alterations in epigenetic regulation are involved in many diseases, including cancer. The advances in our understanding of the impact of epigenetics in development and disease were discussed at a recent Keystone symposium.

引用

页码：2089 / 2094

页数：6

共 45 条

[1] The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly [J].

Ahmad, K ;

Henikoff, S .

MOLECULAR CELL, 2002, 9 (06) :1191-1200

[2]

[Anonymous], 2004, Novartis Foundation Symposium

[3] Inheritance of Polycomb-dependent chromosomal interactions in Drosophila [J].

Bantignies, F ;

Grimaud, C ;

Lavrov, S ;

Gabut, M ;

Cavalli, G .

GENES & DEVELOPMENT, 2003, 17 (19) :2406-2420

[4]

BAROUX C, 2006, IN PRESS GENES DEV

[5] An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse [J].

Blewitt, ME ;

Vickaryous, NK ;

Hemley, SJ ;

Ashe, A ;

Bruxner, TJ ;

Preis, JI ;

Arkell, R ;

Whitelaw, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (21) :7629-7634

[6] Core transcriptional regulatory circuitry in human embryonic stem cells [J].

Boyer, LA ;

Lee, TI ;

Cole, MF ;

Johnstone, SE ;

Levine, SS ;

Zucker, JR ;

Guenther, MG ;

Kumar, RM ;

Murray, HL ;

Jenner, RG ;

Gifford, DK ;

Melton, DA ;

Jaenisch, R ;

Young, RA .

CELL, 2005, 122 (06) :947-956

[7]

BOYER LA, 2006, IN PRESS NATURE

[8] The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis [J].

Cavalli, G ;

Paro, R .

CELL, 1998, 93 (04) :505-518

[9] Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses [J].

Chen, WY ;

Wang, DH ;

Yen, RWC ;

Luo, JY ;

Gu, W ;

Baylin, SB .

CELL, 2005, 123 (03) :437-448

[10] Capturing chromosome conformation [J].

Dekker, J ;

Rippe, K ;

Dekker, M ;

Kleckner, N .

SCIENCE, 2002, 295 (5558) :1306-1311

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