Airway basophil and mast cell density in patients with bronchial asthma: Relationship to bronchial hyperresponsiveness

被引:59
作者
Koshino, T [1 ]
Arai, Y [1 ]
Miyamoto, Y [1 ]
Sano, Y [1 ]
Itami, M [1 ]
Teshima, S [1 ]
Hirai, K [1 ]
Takaishi, T [1 ]
Ito, K [1 ]
Morita, Y [1 ]
机构
[1] UNIV TOKYO, FAC MED, DEPT MED & PHYS THERAPY, BUNKYO KU, TOKYO 113, JAPAN
关键词
D O I
10.3109/02770909609054536
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
We investigated the role of basophils and mast cells in the pathogenesis of bronchial asthma. Eight asthmatics (6 atopic, 2 nonatopic) and 6 control subjects were enrolled in this study. Bronchial responsiveness to acetylcholine (PC(20)ACh) was measured in asthmatics, and endobronchial biopsy from right upper lobe bronchus was performed on the same day. Basophils and mast cells in the airways were identified by immunohistochemistry using a monoclonal antibody against tryptase and anti-IgE. The number of basophils of asthmatics was 52.2 +/- 12.5/mm(2). In contrast, no basophils were found in the airways of control subjects. There was a significant increase of number of mast cells in the asthma group compared to the control group (168.6 +/- 32.6 vs. 22.3 +/- 6.1, p < 0.01). There was an inverse correlation between airway basophil and mast cell numbers and PC(20)ACh (r = -0.82, r = 0.72, p < 0.05). These findings suggest a possible role for basophils and mast cells in the pathophysiology of asthma.
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页码:89 / 95
页数:7
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