Heating under High-Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa)

被引：113

作者：

Hartwig, Jan ^{[1
]}

Ceylan, Sascha ^{[1
]}

Kupracz, Lukas ^{[1
]}

Coutable, Ludovic ^{[1
]}

Kirschning, Andreas ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 37期

关键词：

Buchwald-Hartwig reaction; flow chemistry; inductive heating; medicinal chemistry; microreactors; MAGNETIC NANOPARTICLES; ORGANIC-SYNTHESIS; THIOPHENE INHIBITORS; FLOW SYNTHESIS; CHEMISTRY;

D O I：

10.1002/anie.201302239

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hot chemistry! High-frequency inductive heating and flow chemistry are an ideal match for high-temperature synthesis. This is demonstrated in the multistep flow synthesis of the neurolepticum olanzapine (Zyprexa) that included three reactions with inductive heating and two purification steps conducted as continuous processes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9813 / 9817

页数：5

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