Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia

被引：102

作者：

Bullivant, John P. ^{[1
]}

Zhao, Shan ^{[1
]}

Willenberg, Brad J. ^{[1
]}

Kozissnik, Bettina ^{[2
,3
]}

Batich, Christopher D. ^{[1
,3
]}

Dobson, Jon ^{[1
,2
,3
]}

机构：

[1] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA

[2] Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL 32611 USA

[3] Univ Florida, Inst Cell Engn & Regenerat Med, Gainesville, FL 32611 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 09期

基金：

美国国家科学基金会;

关键词：

Feraheme; magnetic fluid hyperthermia; magnetic nanoparticles; MRI contrast; NANOPARTICLES; MR;

D O I：

10.3390/ijms140917501

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Feraheme, is a recently FDA-cleared superparamagnetic iron oxide nanoparticle (SPION)-based MRI contrast agent that is also employed in the treatment of iron deficiency anemia. Feraheme nanoparticles have a hydrodynamic diameter of 30 nm and consist of iron oxide crystallites complexed with a low molecular weight, semi-synthetic carbohydrate. These features are attractive for other potential biomedical applications such as magnetic fluid hyperthermia (MFH), since the carboxylated polymer coating affords functionalization of the particle surface and the size allows for accumulation in highly vascularized tumors via the enhanced permeability and retention effect. This work presents morphological and magnetic characterization of Feraheme by transmission electron microscopy (TEM), Energy dispersive X-ray spectroscopy (EDX), and superconducting quantum interference device (SQUID) magnetometry. Additionally, the results of an initial evaluation of the suitability of Feraheme for MFH applications are described, and the data indicate the particles possess promising properties for this application.

引用

页码：17501 / 17510

页数：10

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