Synthesis and properties of axially-chiral N-(2,6-disubstituted)phenyl triazolones

被引:21
作者
Brown, RJ
Annis, G
Casalnuovo, A
Chan, D
Shapiro, R
Marshall, WJ
机构
[1] DuPont Crop Protect, Stine Haskell Res Ctr, Newark, DE 19714 USA
[2] DuPont Co Inc, Expt Stn, Dept Cent Res & Dev, Wilmington, DE 19880 USA
关键词
atropisomers; triazolones;
D O I
10.1016/j.tet.2004.03.056
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Certain ortho-substituted phenyl triazolone compounds are fungicidal. When two ortho-substituents are present, stable atropisomers can be isolated. Several methods for resolving racemic intermediates into the enantiomers are described, including separations of diasteromeric ester derivatives and diasteromeric salts. The intermediates were converted into products in which the absolute configuration can be correlated to biological activity. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4361 / 4375
页数:15
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