A PNA4 quadruplex

被引：54

作者：

Krishnan-Ghosh, Y ^{[1
]}

Stephens, E ^{[1
]}

Balasubramanian, S ^{[1
]}

机构：

[1] Univ Cambridge, Chem Labs, Cambridge CB2 1EW, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 19期

关键词：

D O I：

10.1021/ja031508f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A tetrameric PNA, TGGG, has been shown to form an intermolecular G-quadruplex. Nanoelectrospray mass spectrometry, combined with solution-phase H/D exchange, established formation of a specific tetramolecular complex. UV melting studies show that this complex undergoes a quadruplex melting transition. This is a novel four-stranded structure that offers the gross structural features of a DNA quadruplex, but without the negatively charged backbone. Copyright © 2003 American Chemical Society.

引用

页码：5944 / 5945

页数：2

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