The correlation of cognitive decline with frontotemporal dementia induced annualized gray matter loss using diffeomorphic morphometry

被引：14

作者：

Avants, B ^{[1
]}

Grossman, MR ^{[1
]}

Gee, JC ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2005年 / 19卷

关键词：

Alzheimer disease; diffeomorphic morphometry; frontotemporal dementia;

D O I：

10.1097/01.wad.0000183083.14939.82

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study uses large deformation medical image registration to analyze, in a disease-specific normalized space, the annual rate of gray matter atrophy caused by frontotemporal dementia (FTD) and its correlation with cognitive decline. The analysis consists of three parts. First, a labeled structural MRI atlas is deformed into the shape of an average FTD brain. Second, annualized FTD-related atrophy of gray matter structures is estimated for each patient in the database. Third, the group-wise annualized atrophy rate caused by FTD is correlated, for each gray matter voxel, with declining performance on cognitive tests. This study gives insight into the relationship between FTD-related progressive cortical atrophy and loss in cognitive function.

引用

页码：S25 / S28

页数：4

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