Thyroid volume and urinary iodine in European schoolchildren: Standardization of values for assessment of iodine deficiency

被引:240
作者
Delange, F
Benker, G
Caron, P
Eber, O
Ott, W
Peter, F
Podoba, J
Simescu, M
Szybinsky, Z
Vertongen, F
Vitti, P
Wiersinga, W
Zamrazil, V
机构
[1] MERCK KGAA,DARMSTADT,GERMANY
[2] CHU RANGUEIL,SERV ENDOCRINOL,F-31054 TOULOUSE,FRANCE
[3] BARMHERZIGE BRUDER HOSP,DEPT INTERNAL MED,GRAZ,AUSTRIA
[4] BUDA CHILDRENS HOSP,BUDAPEST,HUNGARY
[5] POSTGRAD MED INST BRATISLAVA,BRATISLAVA,SLOVAKIA
[6] INST ENDOCRINOL,BUCHAREST,ROMANIA
[7] JAGIELLONIAN UNIV,DEPT ENDOCRINOL,KRAKOW,POLAND
[8] UNIV BRUSSELS,DEPT CLIN CHEM,BRUSSELS,BELGIUM
[9] UNIV PISA,INST ENDOCRINOL,PISA,ITALY
[10] UNIV AMSTERDAM,ACAD MED CTR,DEPT ENDOCRINOL,NL-1105 AZ AMSTERDAM,NETHERLANDS
[11] INST ENDOCRINOL,PRAGUE,CZECH REPUBLIC
关键词
D O I
10.1530/eje.0.1360180
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Up to 1992, most European countries used to be moderately to severely iodine deficient. The present study aimed at evaluating possible changes in the status of iodine nutrition in 12 European countries during the past few years. Thyroid volume was measured by ultrasonography in 7599 schoolchildren aged 7-15 years in one to fifteen sites in The Netherlands, Belgium, Luxemburg, France, Germany, Austria, Italy, Poland, the Czech and Slovak Republics, Hungary and Romania, The concentrations of urinary iodine were measured in 5709 of them. A mobile unit (ThyroMobil van) equipped with a sonographic device and facilities for the collection of urine samples visited all sites in the 12 countries. All ultrasounds and all urinary iodine assays were performed by the same investigators, The status of iodine nutrition in schoolchildren has markedly improved in many European countries and is presently normal in The Netherlands, France and Slovakia. It remains unchanged in other countries such as Belgium. There is an inverse relationship between urinary iodine and thyroid volume in schoolchildren in Europe. Goiter occurs as soon as the urinary iodine is below a critical threshold of 10 mu g/dl. Its prevalence is up to 10 to 40% in some remote European areas. This work produced updated recommendations for the normal volume of the thyroid measured by ultrasonography as a function of age, sex and body surface area in iodine-replete schoolchildren in Europe. This study proposes a method for a standardized evaluation of iodine nutrition on a continental basis, which could be used in other continents.
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页码:180 / 187
页数:8
相关论文
共 34 条
[1]  
Altman DG, 1990, PRACTICAL STAT MED R
[2]   Iodine-induced thyrotoxicosis in Kivu, Zaire [J].
Bourdoux, PP ;
Ermans, AM ;
Mukalay, AMW ;
Filetti, S ;
Vigneri, R .
LANCET, 1996, 347 (9000) :552-553
[3]   VOLUMETRIC-ANALYSIS OF THYROID LOBES BY REAL-TIME ULTRASOUND [J].
BRUNN, J ;
BLOCK, U ;
RUF, G ;
BOS, I ;
KUNZE, WP ;
SCRIBA, PC .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1981, 106 (41) :1338-1340
[4]   IODINE DEFICIENCY DISEASES IN SWITZERLAND 100 YEARS AFTER KOCHER,THEODOR SURVEY - A HISTORICAL REVIEW WITH SOME NEW GOITER PREVALENCE DATA [J].
BURGI, H ;
SUPERSAXO, Z ;
SELZ, B .
ACTA ENDOCRINOLOGICA, 1990, 123 (06) :577-590
[5]  
Chambers JM., 1983, WADSWORTH
[6]  
CLUGSTON C, 1996, LANCET, V347, P1051
[7]  
DELANGE F, 1986, BIOL NEONATE, V49, P322, DOI 10.1159/000242547
[8]  
Delange F., 1993, IODINE DEFICIENCY EU
[9]  
Delange F., 1994, THYROID INT, V3, P1
[10]  
Delange F, 1995, CLIN PAEDIAT ENDOCRI, P397