Regulation of RNA polymerases I and III by the retinoblastoma protein: A mechanism for growth control?

被引：91

作者：

White, RJ

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(96)10067-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The retinoblastoma protein, RE, is an important tumour suppressor. Recent studies have shown that it inhibits the synthesis of both rRNA and tRNA by RNA polymerases I and III. Suppression of these important determinants of biosynthetic capacity might provide a mechanism for restraining cell growth. Loss of this control could constitute one step towards tumour progression.

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页码：77 / 80

页数：4

相关论文

共 33 条

[1] TRANSCRIPTIONAL CONTROL BY E2F [J].

ADAMS, PD ;

KAELIN, WG .

SEMINARS IN CANCER BIOLOGY, 1995, 6 (02) :99-108

[2] EFFECT OF PROTEIN DEGRADATION ON CELLULAR GROWTH-CHARACTERISTICS [J].

BAXTER, GC ;

STANNERS, CP .

JOURNAL OF CELLULAR PHYSIOLOGY, 1978, 96 (02) :139-145

[3] CONTINUOUS PROTEIN-SYNTHESIS IS REQUIRED TO MAINTAIN PROBABILITY OF ENTRY INTO S-PHASE [J].

BROOKS, RF .

CELL, 1977, 12 (01) :311-317

[4] ACTIVITY OF RNA-POLYMERASE-I TRANSCRIPTION FACTOR UBF BLOCKED BY RB GENE-PRODUCT [J].

CAVANAUGH, AH ;

HEMPEL, WM ;

TAYLOR, LJ ;

ROGALSKY, V ;

TODOROV, G ;

ROTHBLUM, LI .

NATURE, 1995, 374 (6518) :177-180

[5]

GELDUSCHEK EP, 1995, CURR OPIN CELL BIOL, V7, P344

[6] How viral oncogenes make the cell cycle [J].

JansenDurr, P .

TRENDS IN GENETICS, 1996, 12 (07) :270-275

[7] CHANGES IN RNA IN RELATION TO GROWTH OF FIBROBLAST .1. AMOUNTS OF MESSENGER-RNA, RIBOSOMAL-RNA, AND TERTIARY RNA IN RESTING AND GROWING CELLS [J].

JOHNSON, LF ;

ABELSON, HT ;

GREEN, H ;

PENMAN, S .

CELL, 1974, 1 (02) :95-100

[8] A SINGLE AMINO-ACID SUBSTITUTION RESULTS IN A RETINOBLASTOMA PROTEIN DEFECTIVE IN PHOSPHORYLATION AND ONCOPROTEIN BINDING [J].

KAYE, FJ ;

KRATZKE, RA ;

GERSTER, JL ;

HOROWITZ, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6922-6926

[9] TRANSCRIPTIONAL CONTROL BY THE RETINOBLASTOMA PROTEIN [J].

KOUZARIDES, T .

SEMINARS IN CANCER BIOLOGY, 1995, 6 (02) :91-98

[10]

LARMINIE CGC, IN PRESS EMBO J

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