Failure of ACAT inhibition to retard atherosclerosis

被引:30
作者
Fazio, S [1 ]
Linton, M [1 ]
机构
[1] Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Nashville, TN 37240 USA
关键词
D O I
10.1056/NEJMe068012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1307 / 1309
页数:3
相关论文
共 14 条
[1]   INHIBITION OF ACYL-COA CHOLESTEROL O-ACYLTRANSFERASE REDUCES THE CHOLESTERYL ESTER ENRICHMENT OF ATHEROSCLEROTIC LESIONS IN THE YUCATAN MICROPIG [J].
BOCAN, TMA ;
MUELLER, SB ;
UHLENDORF, PD ;
BROWN, EQ ;
MAZUR, MJ ;
BLACK, AE .
ATHEROSCLEROSIS, 1993, 99 (02) :175-186
[2]   Focus on high-density lipoproteins in reducing cardiovascular risk [J].
Brewer, HB .
AMERICAN HEART JOURNAL, 2004, 148 (01) :S14-S18
[3]  
BROWN MS, 1980, J BIOL CHEM, V255, P9344
[4]   Mammalian acyl-CoA: cholesterol acyltransferases [J].
Buhman, KF ;
Accad, M ;
Farese, RV .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1529 (1-3) :142-154
[5]  
DOVE DE, 2004, ARTERIOSCL THROM VAS, V25, P128
[6]   Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages [J].
Fazio, S ;
Major, AS ;
Swift, LL ;
Gleaves, LA ;
Accad, M ;
Linton, MF ;
Farese, RV .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (02) :163-171
[7]   Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) inhibitors as hypolipidemic and antiatherosclerosis drugs [J].
Leon, C ;
Hill, JS ;
Wasan, KM .
PHARMACEUTICAL RESEARCH, 2005, 22 (10) :1578-1588
[8]   Effect of ACAT inhibition on the progression of coronary atherosclerosis [J].
Nissen, SE ;
Tuzcu, EM ;
Brewer, HB ;
Sipahi, I ;
Nicholls, SJ ;
Ganz, P ;
Schoenhagen, P ;
Waters, DD ;
Pepine, CJ ;
Crowe, TD ;
Davidson, MH ;
Deanfield, JE ;
Wisniewski, LM ;
Hanyok, JJ ;
Kassalow, LM .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (12) :1253-1263
[9]   Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes - A randomized controlled trial [J].
Nissen, SE ;
Tsunoda, T ;
Tuzcu, EM ;
Schoenhagen, P ;
Cooper, CJ ;
Yasin, M ;
Eaton, GM ;
Lauer, MA ;
Sheldon, WS ;
Grines, CL ;
Halpern, S ;
Crowe, T ;
Blankenship, JC ;
Kerensky, R .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (17) :2292-2300
[10]   Preferential pharmacological inhibition of macrophage ACAT increases plaque formation in mouse and rabbit models of atherogenesis [J].
Perrey, S ;
Legendre, C ;
Matsuura, A ;
Guffroy, C ;
Binet, J ;
Ohbayashi, S ;
Tanaka, T ;
Ortuno, JC ;
Matsukura, T ;
Laugel, T ;
Padovani, P ;
Bellamy, F ;
Edgar, AD .
ATHEROSCLEROSIS, 2001, 155 (02) :359-370