Distinct type-2A protein phosphatases activate HMGCoA reductase and acetyl-CoA carboxylase in liver

被引：21

作者：

Gaussin, V

Skarlas, P

Ching, YP

Hardie, DG

Hue, L

机构：

[1] UNIV CATHOLIQUE LOUVAIN,SCH MED,INT INST CELLULAR & MOL PATHOL,HORMONE & METAB RES UNIT,B-1200 BRUSSELS,BELGIUM

[2] UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND

来源：

FEBS LETTERS | 1997年 / 413卷 / 01期

基金：

英国惠康基金;

关键词：

acetyl-CoA carboxylase; AMP-activated protein kinase; glutamine; HMGCoA reductase; protein phosphatase-2A;

D O I：

10.1016/S0014-5793(97)00890-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acetyl-CoA carboxylase and HMGCoA reductase are inactivated by the same AMP-activated protein kinase and are activated by type-2A protein phosphatase. To determine whether the same species of protein phosphatase-2A were involved, we studied the interconversion of acetyl-CoA carboxylase and HMGCoA reductase in isolated rat hepatocytes. We show that (i) these enzymes are differently regulated in hepatocytes and (ii) the species of type-2A protein phosphatase involved in their activation are different and can be separated by anion-exchange chromatography. (C) 1997 Federation of European Biochemical Societies.

引用

页码：115 / 118

页数：4

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