Osmotic scan ektacytometry in clinical diagnosis

被引：25

作者：

Johnson, RM ^{[1
]}

Ravindranath, Y ^{[1
]}

机构：

[1] WAYNE STATE UNIV, SCH MED, DEPT PEDIAT, DETROIT, MI 48201 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 1996年 / 18卷 / 02期

关键词：

hemolytic anemia; hereditary spherocytosis; hereditary elliptocytosis; Sickle cell anemia; ektacytometry;

D O I：

10.1097/00043426-199605000-00005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: The use of red blood cell deformability measurements in the diagnosis of hemolytic anemia is reviewed. Patients and Methods: Results from 500 individuals are discussed. Erythrocytes were characterized by the automated measurement of cell deformability as the tonicity of the medium is varied (osmotic scan ektacytometry). Results: The measurement yields a reliable identification of hemolytic anemias caused by deficiencies or abnormalities in erythrocyte structural proteins. In addition, it can, with good reliability, signal the presence of a glycolytic enzyme deficiency. The scan is complete in 15 min, and can therefore give a rapid indication of the type of hemolytic anemia. The osmotic scans of other hemolytic anemias are also discussed. Conclusion: The analysis of red blood cell deformability can offer a valuable addition to diagnostic methods in hemolytic anemia.

引用

页码：122 / 129

页数：8

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