Localization of intestinal intralepithelial T lymphocytes involves regulation of αEβ7 expression by transforming growth factor-β

被引：38

作者：

Suzuki, R

Nakao, A ^{[1
]}

Kanamaru, Y

Okumura, K

Ogawa, H

Ra, C

机构：

[1] Juntendo Univ, Sch Med, Atopy Allergy Res Ctr, Tokyo 1138421, Japan

[2] Juntendo Univ, Sch Med, Dept Pediat, Tokyo 1138421, Japan

[3] Juntendo Univ, Sch Med, Dept Nephrol, Tokyo 1138421, Japan

来源：

INTERNATIONAL IMMUNOLOGY | 2002年 / 14卷 / 04期

关键词：

mucosal immunity; transgenic mice; Smad7;

D O I：

10.1093/intimm/14.4.339

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Induction of alpha(E)beta(7) expression on T cells by transforming growth factor (TGF)-beta is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of alpha(E)beta(7) expression on T cells by TGF-beta is critical for the selective localization of intestinal IEL in the epithelial area. We have recently established transgenic mice expressing Smad7 under the control of a distal Ick promoter where TGF-beta/Smad signaling is specifically blocked in mature T cells. Here we showed that TGF-beta-mediated up-regulation of alpha(E)beta(7) was impaired on T cells isolated from the Smad7 transgenic mice associated with reduced numbers of intestinal IEL when compared with that in wild-type littermates. These results indicated that failure to induce alpha(E)beta(7) on T cells by TGF-beta resulted in reduced numbers of intestinal IEL, suggesting the importance of alpha(E)beta(7) expression by TGF-beta in selective localization of intestinal IEL.

引用

页码：339 / 345

页数：7

共 19 条

[1] T-lymphocyte-epithelial-cell interactions:: integrin αE(CD103)β7, LEEP-CAM and chemokines [J].