Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations

被引：102

作者：

Fitschen, Peter J. ^{[1
]}

Wilson, Gabriel J. ^{[2
]}

Wilson, Jacob M. ^{[3
]}

Wilund, Kenneth R. ^{[1
,4
]}

机构：

[1] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA

[2] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08903 USA

[3] Univ Tampa, Dept Hlth Sci & Human Performance, Tampa, FL 33606 USA

[4] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA

来源：

NUTRITION | 2013年 / 29卷 / 01期

关键词：

Chronic disease; Exercise; beta-Hydroxy-beta-methylbutyrate B; Lean mass; Muscle; Wasting; TUMOR-BEARING RATS; SKELETAL-MUSCLE; PROTEIN-METABOLISM; BODY-COMPOSITION; CELL-PROLIFERATION; RESISTANCE-EXERCISE; STRENGTH GAINS; WEIGHT-LOSS; ARGININE; HMB;

D O I：

10.1016/j.nut.2012.05.005

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Muscle loss is common during aging and chronic diseases, such as cancer and acquired immunodeficiency syndrome. Moreover, muscle loss has been correlated with decreased physical function, quality of life, and mortality in these populations. Therefore, interventions to counteract muscle loss in the elderly and clinical populations are needed. Recently, the efficacy of the leucine metabolite, beta-hydroxy-beta-methylbutyrate (HMB), to maintain muscle mass has been investigated in these populations. Many studies have found increases in lean mass and strength in the elderly and clinical populations when using HMB; however, not all studies have found beneficial effects of HMB supplementation. The present review summarizes published human studies investigating the efficacy of HMB supplementation in the elderly and clinical populations. In addition, the mechanisms by which HMB may exert its effects are summarized and future research directions are suggested. (C) 2013 Elsevier Inc. All rights reserved.

引用

收藏

页码：29 / 36

页数：8

相关论文

共 58 条

[1]

Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? [J].

Andreyev, HJN ;

Norman, AR ;

Oates, J ;

Cunningham, D .

EUROPEAN JOURNAL OF CANCER, 1998, 34 (04) :503-509

[2]

β-hydroxy-β-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia [J].

Aversa, Zaira ;

Bonetto, Andrea ;

Costelli, Paola ;

Minero, Valerio Giacomo ;

Penna, Fabio ;

Baccino, Francesco Maria ;

Lucia, Simone ;

Rossi Fanelli, Filippo ;

Muscaritoli, Maurizio .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2011, 38 (03) :713-720

[3]

Year-long Changes in Protein Metabolism in Elderly Men and Women Supplemented With a Nutrition Cocktail of β-Hydroxy-β-methylbutyrate (HMB), L-Arginine, and L-Lysine [J].

Baier, Shawn ;

Johannsen, Darcy ;

Abumrad, Naji ;

Rathmacher, John A. ;

Nissen, Steven ;

Flakoll, Paul .

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2009, 33 (01) :71-82

[4]

SIMPLE RECORDING GRIP STRENGTH DEVICE [J].

CABE, PA ;

TILSON, HA ;

MITCHELL, CL ;

DENNIS, R .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1978, 8 (01) :101-102

[5]

β-hydoxy-β-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner [J].

Caperuto, Erico Chagas ;

Tomatieli, Ronaldo Vagner ;

Colquhoun, Alison ;

Leite Seelaender, Marilia Cerqueira ;

Pereira Costa Rosa, Luis Fernando Bicudo .

CLINICAL NUTRITION, 2007, 26 (01) :117-122

[6]

Nutritional treatment for acquired immunodeficiency virus-associated wasting using β-hydroxy β-methylbutyrate, glutamine, and arginine:: A randomized, double-blind, placebo-controlled study [J].

Clark, RH ;

Feleke, G ;

Din, M ;

Yasmin, T ;

Singh, G ;

Khan, FA ;

Rathmacher, JA .

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2000, 24 (03) :133-139

[7]

Nutritional effect of oral supplement enriched in beta-hydroxy-beta-methylbutyrate, glutamine and arginine on resting metabolic rate after laparoscopic gastric bypass [J].

Clements, Ronald H. ;

Saraf, Neha ;

Kakade, Manasi ;

Yellumahanthi, Kishore ;

White, Merritt ;

Hackett, Jo Ann .

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2011, 25 (05) :1376-1382

[8]

Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies [J].

Dodson, Shontelle ;

Baracos, Vickie E. ;

Jatoi, Aminah ;

Evans, William J. ;

Cella, David ;

Dalton, James T. ;

Steiner, Mitchell S. .

ANNUAL REVIEW OF MEDICINE, VOL 62, 2011, 2011, 62 :265-279

[9]

Signaling pathways initiated by β-hydroxy-β-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli [J].

Eley, Helen L. ;

Russell, Steven T. ;

Baxter, Jeffrey H. ;

Mukerji, Pradip ;

Tisdale, Michael J. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (04) :E923-E931

[10]

Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-α and angiotensin II by β-hydroxy-β-methylbutyrate [J].

Eley, Helen L. ;

Russell, Steven T. ;

Tisdale, Michael J. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 295 (06) :E1417-E1426

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