Diagnosis of Cystic Fibrosis by Sweat Testing: Age-Specific Reference Intervals

被引:55
作者
Mishra, Avantika [2 ,3 ]
Greaves, Ronda [4 ]
Smith, Katherine [5 ]
Carlin, John B. [5 ,7 ]
Wootton, Andrew [3 ]
Stirling, Rob [6 ]
Massie, John [1 ,7 ]
机构
[1] Royal Childrens Hosp, Dept Resp Med, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia
[2] Royal Childrens Hosp, VCGS Pathol, Dept Biochem Genet, Parkville, Vic 3052, Australia
[3] RMIT Univ, Sch Med Sci Lab Med, Bundoora, Vic, Australia
[4] Royal Childrens Hosp, Lab Serv Complex Biochem, Parkville, Vic 3052, Australia
[5] Royal Childrens Hosp, Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Parkville, Vic 3052, Australia
[6] Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia
[7] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
关键词
D O I
10.1016/j.jpeds.2008.04.067
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To develop reference intervals (RIs) for sweat chloride and sodium in healthy children, adolescents, and adults. Study design Healthy, unrelated subjects aged from 5 to >50 years and subjects who were pancreatic insufficient with cystic fibrosis (CF) were recruited. Sweat collection was performed on all subjects with die Weseor Macroduct system. Sweat electrolytes were analyzed with direct ion selective electrodes. Delta F508 mutation analysis was performed on the healthy subjects >= 15 years old. Results A total of 282 healthy and 40 subjects with CF were included for analysis. There was no overlap of sweat chloride between the group with CF and the group without CF, but there was some overlap of sweat sodium. Sweat chloride increased with age, with the rate of increase slowing progressively to zero after the age of 19 years. The estimated median (95% RI) for sweat chloride were: 5 to 9 years, 13 mmol/L (1-39 mmol/L); 10 to 14 years, 18mmol/L (3-47 nmol/L); 15 to 19 years, 20 mmol/L (3-51mmol/L); and 20+ years 23 mmol/L, (5-56mmol/L). Conclusions We have successfully developed the age-related RI for sweat electrolytes, which will be useful for clinicians interpreting sweat test results from children, adolescents, and adults. (J Pediatr 2008;153:758-63)
引用
收藏
页码:758 / 763
页数:6
相关论文
共 30 条
[1]   SWEAT TEST RESULTS IN NORMAL PERSONS OF DIFFERENT AGES COMPARED WITH FAMILIES WITH FIBROCYSTIC DISEASE OF THE PANCREAS [J].
ANDERSON, CM ;
FREEMAN, M .
ARCHIVES OF DISEASE IN CHILDHOOD, 1960, 35 (184) :581-587
[2]  
ANDREWS BF, 1962, PEDIATRICS, V29, P204
[3]   MILD CYSTIC-FIBROSIS AND NORMAL OR BORDERLINE SWEAT TEST IN PATIENTS WITH THE 3849+10 KB C-]T MUTATION [J].
AUGARTEN, A ;
KEREM, BS ;
YAHAV, Y ;
NOIMAN, S ;
RIVLIN, Y ;
TAL, A ;
BLAU, H ;
BENTUR, L ;
SZEINBERG, A ;
KEREM, E ;
GAZIT, E .
LANCET, 1993, 342 (8862) :25-26
[4]   The significance of sweat Cl/Na ratio in patients with borderline sweat test [J].
Augarten, A ;
Hacham, S ;
Kerem, E ;
Kerem, BS ;
Szeinberg, A ;
Laufer, J ;
Doolman, R ;
Altshuler, R ;
Blau, H ;
Bentur, L ;
Gazit, E ;
Katznelson, D ;
Yahav, Y .
PEDIATRIC PULMONOLOGY, 1995, 20 (06) :369-371
[5]   SWEAT CHLORIDE CONCENTRATION IN ADULTS WITH PULMONARY-DISEASES [J].
DAVIS, PB ;
DELRIO, S ;
MUNTZ, JA ;
DIECKMAN, L .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1983, 128 (01) :34-37
[6]   Cystic fibrosis: terminology and diagnostic algorithms [J].
De Boeck, K. ;
Wilschanski, M. ;
Castellani, C. ;
Taylor, C. ;
Cuppens, H. ;
Dodge, J. ;
Sinaasappel, M. .
THORAX, 2006, 61 (07) :627-635
[7]  
DISANTAGNESE PA, 1953, PEDIATRICS, V12, P549
[8]  
Farrell PM, 1996, PEDIATRICS, V97, P524
[9]   SWEAT CHLORIDE CONCENTRATION - A COMPARATIVE STUDY IN CHILDREN WITH BRONCHIAL ASTHMA AND WITH CYSTIC FIBROSIS [J].
GHARIB, R ;
JOOS, HA ;
HILTY, LB .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1965, 109 (01) :66-+
[10]  
GIBSON LE, 1959, PEDIATRICS, V23, P545