Induced pluripotent stem cells in medicine and biology

被引：186

作者：

Takahashi, Kazutoshi ^{[1
]}

Yamanaka, Shinya ^{[1
,2
]}

机构：

[1] Kyoto Univ, Ctr iPS Cell Res & Applicat, Kyoto 6068507, Japan

[2] Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

来源：

DEVELOPMENT | 2013年 / 140卷 / 12期

关键词：

Disease modeling; Reprogramming; Stem cell; Therapy; iPSCs; MOUSE EPIBLAST; HUMAN FIBROBLASTS; CLINICAL-TRIAL; CORD BLOOD; T-CELLS; GENERATION; LINES; DIFFERENTIATION; EXPRESSION; DERIVATION;

D O I：

10.1242/dev.092551

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Differentiated cells can be reprogrammed to pluripotency and other cell fates by treatment with defined factors. The discovery of induced pluripotent stem cells (iPSCs) has opened up unprecedented opportunities in the pharmaceutical industry, in the clinic and in laboratories. In particular, the medical applications of human iPSCs in disease modeling and stem cell therapy have been progressing rapidly. The ability to induce cell fate conversion is attractive not only for these applications, but also for basic research fields, such as development, cancer, epigenetics and aging.

引用

收藏

页码：2457 / 2461

页数：5

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