Stem-cell transplantation in myocardial infarction: A status report

被引:66
作者
Lee, MS
Makkar, RR
机构
[1] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Cardiac Catheterizat Lab, Div Cardiol,Sch Med, Los Angeles, CA 90048 USA
[2] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, New York, NY 10032 USA
关键词
D O I
10.7326/0003-4819-140-9-200405040-00013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myocardial infarction is the leading cause of congestive heart failure and death in the industrialized world. Current therapy is limited in preventing the progression of ventricular remodeling and congestive heart failure. Recent interest has focused on stem cells, which are undifferentiated and pluripotent cells that can proliferate, potentially self-renew, and differentiate into cardiomyocytes. Myocardial regeneration with stem-cell transplantation is a possible treatment option to reverse the deleterious hemodynamic and neurohormonal effects that occur after myocardial infarction and can lead to congestive heart failure. Various preclinical animal studies show the potential to regenerate myocardium and improve perfusion to the infarct area to improve cardiac function but also suggest that stem cells may have proarrhythmic effects. Early phase I clinical studies indicate that stem-cell transplantation is feasible and may have beneficial effects on ventricular remodeling after myocardial infarction. Future randomized clinical trials will establish the magnitude of the benefit and the effects on arrhythmias after stem-cell therapy.
引用
收藏
页码:729 / 737
页数:9
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