Engineered plants with elevated vitamin E: a nutraceutical success story

被引：35

作者：

Ajjawi, I ^{[1
]}

Shintani, D ^{[1
]}

机构：

[1] Univ Nevada, Dept Biochem, Reno, NV 89557 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2004年 / 22卷 / 03期

关键词：

D O I：

10.1016/j.tibtech.2004.01.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Vitamin E has been touted as a panacea for age-related diseases, including cardiovascular disease and Alzheimer's disease and, thus, the demand for this nutraceutical has increased dramatically in recent years.This diamond has, in turn, driven research to increase vitamin E production from plant sources. We have summarized the cumulative work of several groups in this area, describing the current status of efforts to bioengineer plants for elevated vitamin E content.

引用

收藏

页码：104 / 107

页数：4

相关论文

共 13 条

[1] Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content [J].

Cahoon, EB ;

Hall, SE ;

Ripp, KG ;

Ganzke, TS ;

Hitz, WD ;

Coughlan, SJ .

NATURE BIOTECHNOLOGY, 2003, 21 (09) :1082-1087

[2] Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis [J].

Collakova, E ;

DellaPenna, D .

PLANT PHYSIOLOGY, 2003, 131 (02) :632-642

[3] 1-deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants [J].

Estévez, JM ;

Cantero, A ;

Reindl, A ;

Reichler, S ;

León, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) :22901-22909

[4] Constitutive overexpression of barley 4-hydroxyphenylpyruvate dioxygenase in tobacco results in elevation of the vitamin E content in seeds but not in leaves [J].

Falk, J ;

Andersen, G ;

Kernebeck, B ;

Krupinska, K .

FEBS LETTERS, 2003, 540 (1-3) :35-40

[5] STUDIES ON PLANT-TISSUE CULTURES .49. PRODUCTION OF TOCOPHEROLS BY CELL-CULTURE OF SAFFLOWER [J].

FURUYA, T ;

YOSHIKAWA, T ;

KIMURA, T ;

KANEKO, H .

PHYTOCHEMISTRY, 1987, 26 (10) :2741-2747

[6] Improving the nutrient composition of plants to enhance human nutrition and health [J].

Grusak, MA ;

DellaPenna, D .

ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1999, 50 :133-161

[7]

Institute of Medicine, 2000, DIET REF INT VIT C V, DOI DOI 10.1016/S0899-9007(00)00596-7

[8] The chemistry and antioxidant properties of tocopherols and tocotrienols [J].

KamalEldin, A ;

Appelqvist, LA .

LIPIDS, 1996, 31 (07) :671-701

[9]

MOSHE R, 1989, PLANT PHYSIOL, V89, P1028

[10] Isolation and characterization of homogentisate phytyltransferase genes from Synechocystis sp PCC 6803 and Arabidopsis [J].

Savidge, B ;

Weiss, JD ;

Wong, YHH ;

Lassner, MW ;

Mitsky, TA ;

Shewmaker, CK ;

Post-Beittenmiller, D ;

Valentin, HE .

PLANT PHYSIOLOGY, 2002, 129 (01) :321-332