Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons

被引：53

作者：

Chen, Han-Qing ^{[1
,2
]}

Wang, Xi-Jin ^{[3
,4
]}

Jin, Zheng-Yu ^{[1
,2
]}

Xu, Xue-Ming ^{[1
,2
]}

Zhao, Jian-Wei ^{[1
,2
]}

Xie, Zheng-Jun ^{[1
,2
]}

机构：

[1] Jiangnan Univ, Sch Food Sci & Technol, Jiangsu 214122, Peoples R China

[2] Jiangnan Univ, State Key Lab Food Sci & Technol, Jiangsu 214122, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Shanghai 200025, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Inst Neurol, Rui Jin Hosp, Shanghai 200025, Peoples R China

来源：

NEUROSCIENCE RESEARCH | 2008年 / 62卷 / 02期

关键词：

Isoflavone; Inflammation; Microglia; Dopaminergic neurodegeneration; Parkinson's disease;

D O I：

10.1016/j.neures.2008.07.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, protective effect of five isoflavones (formononetin, daidzein, pratensein, calycosin and irilone) from Trifolium pratense on lipopolysaccharide-induced dopaminergic neurodegeneration was studied for the first time. The results showed that all five isoflavones attenuated LPS-induced decrease in dopamine uptake and the number of dopaminergic neurons in a dose-dependent manner in rat mesencephalic neuron-glia cultures. Moreover, they also significantly inhibited LPS-induced activation of microglia and production of tumor necrosis factor-a, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. In addition, the rank order of protective potency of five isoflavones was: pratensein > daidzein > calycosin > formononetin > irilone. This study suggested that all five isoflavones protected dopaminergic neurons against LPS-induced injury through inhibition of microglia activation and proinflammatory factors generation. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：123 / 130

页数：8

共 51 条

[1] Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor β [J].