Molecular characterization of frog chromogranin B reveals conservation of selective sequences encoding potential novel regulatory peptides

被引：9

作者：

Aït-Ali, D ^{[1
]}

Turquier, V ^{[1
]}

Alexandre, D ^{[1
]}

Grumolato, L ^{[1
]}

Jégou, S ^{[1
]}

Vaudry, H ^{[1
]}

Anouar, Y ^{[1
]}

机构：

[1] Univ Rouen, UA CNRS, INSERM U413,European Inst Peptide Res, Lab Cellular & Mol Neuroendocrinol, F-76821 Mont St Aignan, France

来源：

FEBS LETTERS | 2002年 / 511卷 / 1-3期

关键词：

chromogranin; 13; secretory protein; peptide precursor; neuroendocrine cell; molecular phylogeny;

D O I：

10.1016/S0014-5793(01)03296-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromogranin B (CgB) is a member of the granin family of neuroendocrine secretory proteins, which has been proposed to play a role in secretory granule biogenesis and as a precursor to bioactive peptides. The cloning of CgB in a phylogenetically distant vertebrate, the frog Rana ridibunda, reveals a modest overall homology (35-40%) with mammalian CgB. However, the sequences of the N- and C-terminal regions are more highly conserved (57-65% amino acid identity) and may give rise to novel regulatory peptides. In frog, intense expression of CgB mRNA was observed in particular structures of the brain and in the distal lobe of the pituitary. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：127 / 132

页数：6

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