trans,trans-2,4-decadienal: Cytotoxicity and effect on glutathione level in human erythroleukemia (HEL) cells

被引：50

作者：

Nappez, C ^{[1
]}

Battu, S ^{[1
]}

Beneytout, JL ^{[1
]}

机构：

[1] FAC MED & PHARM,CNRS,URA 1485,F-87025 LIMOGES,FRANCE

来源：

CANCER LETTERS | 1996年 / 99卷 / 01期

关键词：

HEL cells; hydroxyalkenals; trans,trans-2,4-decadienal; glutathione;

D O I：

10.1016/0304-3835(95)04045-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of trans,trans-2,4-decadienal (DDE), an isomer of a lipid peroxidation product were investigated on the human erythroleukemia cell line (HEL TIB 180). DDE strongly inhibits cell growth and affects cell viability without any differentiating effects. DDE treatment of HEL cells leads to a marked variation of the cellular glutathione level (GSH) and is involved in the beginning of DNA fragmentation.

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页码：115 / 119

页数：5

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