Antimicrobial steroids from the fungus Fomitopsis pinicola

被引：194

作者：

Keller, AC ^{[1
]}

Maillard, MP ^{[1
]}

Hostettmann, K ^{[1
]}

机构：

[1] UNIV LAUSANNE, INST PHARMACOGNOSIE & PHYTOCHIM, BEP, CH-1015 LAUSANNE, SWITZERLAND

来源：

PHYTOCHEMISTRY | 1996年 / 41卷 / 04期

关键词：

Fomitopsis pinicola; Polyporaceae; steroids; lanostane; 3 alpha-(4-carboxymethyl-3-hydroxy-3-methylbutanoyloxy)-lanosta-8,24-dien-21-oic acid; fomitopsic acid;

D O I：

10.1016/0031-9422(95)00762-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Phytochemical examination of the dichloromethane extract of the European fungus Fomitopsis pinicola led to the isolation of a new lanostanoid derivative identified from spectral and chemical evidences as 3 alpha-(4-carboxymethyl-3-hydroxy-3-methylbutanoyloxy)-lanosta-8,24-dien-21-oic acid. In addition, seven known triterpenes, polyporenic acid C, 3 alpha-acetyloxylanosta-8,24-dien-21-oic acid, ergosta-7,22-dien-3 beta-ol, 21-hydroxylanosta-8,24-dien-3-one, pinicolic acid A, trametenolic acid B and pachymic acid, were also isolated. Antimicrobial activity against Bacillus subtilis in a TLC bioassay was observed for five of the isolated steroids.

引用

页码：1041 / 1046

页数：6

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