Alpha-fetoprotein gene regulation: lessons from transgenic mice

被引：73

作者：

Spear, BT ^{[1
]}

机构：

[1] Univ Kentucky, Dept Microbiol & Immunol, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Pathol & Lab Med, Lexington, KY 40536 USA

来源：

SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 02期

关键词：

liver; transcription; cancer; regeneration; development;

D O I：

10.1006/scbi.1998.0087

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mouse alpha-fetoprotein (AFP) gene provides an excellent model system to study developmental gene activation and different aspects of liver-specific transcriptional control: AFP is activated early in hepatogenesis, repressed post-natally, and can be reactivated during liver regeneration and in hepatocellular carcinomas. Transgenic studies have also revealed that AFP enhancers, when linked individually to a heterologous promoter, can confer zonal control ill the adult liver. Continued transgenic studies, combined with analysis using in vitro and tissue culture systems, will help elucidate mechanisms of transcriptional regulation during liver development and hepatocarcinogenesis.

引用

页码：109 / 116

页数：8

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