The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance

被引：12

作者：

Alhaddad, Lina ^{[1
,2
]}

Osipov, Andreyan N. ^{[1
,3
,4
]}

Leonov, Sergey ^{[1
,5
]}

机构：

[1] Moscow Inst Phys & Technol, Sch Biol & Med Phys, Dolgoprudnyi 141700, Russia

[2] Damascus Univ, Fac Sci, Dept Environm Sci, POB 30621, Damascus, Syria

[3] Fed Med Biol Agcy SRC FMBC, Burnasyan Fed Med Biophys Ctr, State Res Ctr, Moscow 123098, Russia

[4] Russian Acad Sci, NN Semenov Res Ctr Chem Phys, Moscow 119991, Russia

[5] Russian Acad Sci, Inst Cell Biophys, Pushchino 142290, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 21期

基金：

俄罗斯基础研究基金会;

关键词：

ionizing radiation; radioresistance; radiosensitivity; cancer stem cells; epithelial mesenchymal transition; polyploid; multinucleated giant cancer cells; EPITHELIAL-MESENCHYMAL TRANSITION; ENDOTHELIAL GROWTH-FACTOR; GLIOMA STEM-CELLS; TUMOR-INITIATING CELLS; STRAND BREAK REPAIR; REGULATORY T-CELLS; DNA-DAMAGE RESPONSE; KAPPA-B ACTIVATION; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; RADIATION-INDUCED APOPTOSIS;

D O I：

10.3390/ijms232113577

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ionizing radiation (IR) has been shown to play a crucial role in the treatment of glioblastoma (GBM; grade IV) and non-small-cell lung cancer (NSCLC). Nevertheless, recent studies have indicated that radiotherapy can offer only palliation owing to the radioresistance of GBM and NSCLC. Therefore, delineating the major radioresistance mechanisms may provide novel therapeutic approaches to sensitize these diseases to IR and improve patient outcomes. This review provides insights into the molecular and cellular mechanisms underlying GBM and NSCLC radioresistance, where it sheds light on the role played by cancer stem cells (CSCs), as well as discusses comprehensively how the cellular dormancy/non-proliferating state and polyploidy impact on their survival and relapse post-IR exposure.

引用

页数：43

共 604 条

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