Interleukin-11: Its biology and prospects for clinical use

被引:15
作者
Grosfeld, JL
Du, XX
Williams, DA
机构
[1] James Whitcomb Riley Hosp Children, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Surg, Pediat Surg Sect, Indianapolis, IN 46202 USA
[3] Indiana Univ, Sch Med, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA
[4] Indiana Univ, Sch Med, Sect Pediat Hematol Oncol, Dept Pediat, Indianapolis, IN 46202 USA
[5] Indiana Univ, Sch Med, Howard Hughes Med Inst, Indianapolis, IN 46202 USA
关键词
D O I
10.1177/014860719902300517
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
IL-11 is a multifunctional cytokine that has pleiotropic effects on a variety of tissue including the bone marrow and intestinal mucosa. IL-11 is useful in elevating the platelet count in cancer patients with chemotherapy-induced thrombocytopenia and has a cytoprotective effect on the bowel mucosa in a variety of causes of gut damage and a trophic effect on the villi after massive bowel resection.
引用
收藏
页码:S67 / S69
页数:3
相关论文
共 19 条
[1]  
ALINAZIR A, 1996, P AN M AM SOC CLIN, V15, P274
[2]   STRUCTURE-FUNCTION-RELATIONSHIPS IN HUMAN INTERLEUKIN-11 - IDENTIFICATION OF REGIONS INVOLVED IN ACTIVITY BY CHEMICAL MODIFICATION AND SITE-DIRECTED MUTAGENESIS [J].
CZUPRYN, MJ ;
MCCOY, JM ;
SCOBLE, HA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (02) :978-985
[3]  
DU XX, 1993, BLOOD, V82, P1016
[4]  
Du XX, 1996, J CELL PHYSIOL, V168, P362
[5]   Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis [J].
Du, XX ;
Liu, Q ;
Yang, ZX ;
Orazi, A ;
Rescorla, FJ ;
Grosfeld, JL ;
Williams, DA .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1997, 272 (03) :G545-G552
[6]  
DU XX, 1994, BLOOD, V83, P33
[7]   Interleukin-11: Review of molecular, cell biology, and clinical use [J].
Du, XX ;
Williams, DA .
BLOOD, 1997, 89 (11) :3897-3908
[8]  
DU XX, 1994, BLOOD, V83, P2030
[9]  
Dykstra Kevin, 1996, Blood, V88, p346A
[10]   Comparison of interleukin-11 and epidermal growth factor on residual small intestine after massive small bowel resection [J].
Fiore, NF ;
Ledniczky, G ;
Liu, Q ;
Orazi, A ;
Du, XX ;
Williams, DA ;
Grosfeld, JL .
JOURNAL OF PEDIATRIC SURGERY, 1998, 33 (01) :24-29