Structural Studies of Copper(I) Complexes of Amyloid-β Peptide Fragments: Formation of Two-Coordinate Bis(histidine) Complexes

被引：132

作者：

Himes, Richard A. ^{[1
]}

Park, Ga Young ^{[1
]}

Siluvai, Gnana Sutha ^{[2
]}

Blackburn, Ninian J. ^{[2
]}

Karlin, Kenneth D. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

[2] OHSU, OGI Sch Sci & Engn, Dept Environm & Biomol Syst, Beaverton, OR 97006 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 47期

关键词：

amyloids; copper; EXAFS spectroscopy; hydrogen peroxide; reactive species;

D O I：

10.1002/anie.200803908

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The beta bind: Copper(I) binds to amyloid β-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)-peptide complexes react with dioxygen to form the reactive oxygen species H2O2, without the need for a third histidine ligand to promote the chemistry. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9084 / 9087

页数：4

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