Hyperuricaemia: more than just a cause of gout?

被引：109

作者：

Katsiki, Niki ^{[1
]}

Karagiannis, Asterios ^{[1
]}

Athyros, Vasilios G. ^{[1
]}

Mikhailidis, Dimitri P. ^{[2
,3
]}

机构：

[1] Aristotle Univ Thessaloniki, Hippocrat Hosp, Propedeut Dept Internal Med 2, GR-54006 Thessaloniki, Greece

[2] UCL, Sch Med, Dept Clin Biochem Vasc Dis Prevent Clin, London NW3 2QG, England

[3] UCL, Sch Med, Dept Surg, London NW3 2QG, England

来源：

JOURNAL OF CARDIOVASCULAR MEDICINE | 2013年 / 14卷 / 06期

关键词：

cardiovascular disease; gout; metabolic syndrome; renal disease; uric acid; vascular risk; SERUM URIC-ACID; PERIPHERAL ARTERIAL-DISEASE; CHRONIC KIDNEY-DISEASE; CORONARY-HEART-DISEASE; INTIMA-MEDIA THICKNESS; FATTY LIVER-DISEASE; TYPE-2; DIABETES-MELLITUS; LOW-GRADE INFLAMMATION; METABOLIC SYNDROME; RISK-FACTORS;

D O I：

10.2459/JCM.0b013e3283595adc

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Traditionally, serum uric acid (SUA) has been implicated in acute gouty arthritis or chronic gouty arthropathy. However, SUA also plays a role in other pathological conditions especially in cardiovascular (CV), metabolic and renal disease. This narrative review considers the significant associations of SUA with kidney function, several CV risk factors and vascular diseases, supporting the concept of assessing hyperuricaemia for reasons other than just gout. Several drugs that reduce CV risk also decrease SUA levels, further improving vascular risk. Therefore, selecting SUA-lowering drugs to treat high-risk patients may prove beneficial in terms of reducing CV risk.

引用

页码：397 / 402

页数：6

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