Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools

被引：49

作者：

Acimovic, Ivana ^{[1
]}

Vilotic, Aleksandra ^{[1
]}

Pesl, Martin ^{[1
,2
]}

Lacampagne, Alain ^{[3
]}

Dvorak, Petr ^{[1
,2
]}

Rotrekl, Vladimir ^{[1
]}

Meli, Albano C. ^{[1
,3
]}

机构：

[1] Masaryk Univ, Fac Med, Dept Biol, Brno 62500, Czech Republic

[2] St Annes Univ Hosp, ICRC, Brno 60200, Czech Republic

[3] Univ Montpellier I, Univ Montpellier 2, INSERM U1046, F-34295 Montpellier, France

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

LONG QT SYNDROME; POLYMORPHIC VENTRICULAR-TACHYCARDIA; PROMOTES CARDIAC DIFFERENTIATION; SHEET MANIPULATION TECHNIQUE; ADULT HUMAN FIBROBLASTS; EMBRYOID BODIES; SMALL-MOLECULE; IPS CELLS; ENHANCES DIFFERENTIATION; ELECTRICAL-STIMULATION;

D O I：

10.1155/2014/512831

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs).

引用

页数：14

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