An architectural framework that may lie at the core of the postsynaptic density

被引：224

作者：

Baron, MK

Boeckers, TM

Vaida, B

Faham, S

Gingery, M

Sawaya, MR

Salyer, D

Gundelfinger, ED

Bowie, JU

机构：

[1] Univ Calif Los Angeles, Inst Mol Biol, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Univ Calif Los Angeles US Dept Energy Inst Genom, Los Angeles, CA 90095 USA

[3] Univ Ulm, Inst Anat & Cell Biol, Ulm, Germany

[4] Leibniz Inst Neurobiol, D-39008 Magdeburg, Germany

来源：

SCIENCE | 2006年 / 311卷 / 5760期

关键词：

D O I：

10.1126/science.1118995

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytosketetat matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.

引用

页码：531 / 535

页数：5

共 33 条

[31] Ca2+-Zn2+ permeable AMPA or kainate receptors:: possible key factors in selective neurodegeneration [J].