Confronting the threat of multidrug-resistant Gram-negative bacteria in critically ill patients

被引:37
作者
Cohen, Jonathan [1 ]
机构
[1] Brighton & Sussex Med Sch, Brighton BN1 9PH, E Sussex, England
关键词
critical care; intensive care; antimicrobial resistance; Gram-negative infection; ANTIMICROBIAL RESISTANCE; CRITICAL-CARE; INFECTIONS; IMPACT;
D O I
10.1093/jac/dks460
中图分类号
R51 [传染病];
学科分类号
100201 [内科学];
摘要
The re-emergence of infection due to multidrug-resistant Gram-negative bacteria in critically ill patients presents particular challenges to clinicians, given the lack of a pipeline of new antibiotics active against these resistant strains. Infected patients have a worse outcome than non-infected patients, although the additional contribution of antimicrobial resistance is less easy to define. Newer and better antibiotics would be welcome, but are unlikely alone to make a major impact on clinical outcomes.
引用
收藏
页码:490 / 491
页数:2
相关论文
共 12 条
[1]
Burden of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay associated with bloodstream infections due to Escherichia coli resistant to third-generation cephalosporins [J].
de Kraker, M. E. A. ;
Wolkewitz, M. ;
Davey, P. G. ;
Koller, W. ;
Berger, J. ;
Nagler, J. ;
Icket, C. ;
Kalenic, S. ;
Horvatic, J. ;
Seifert, H. ;
Kaasch, A. ;
Paniara, O. ;
Argyropoulou, A. ;
Bompola, M. ;
Smyth, E. ;
Skally, M. ;
Raglio, A. ;
Dumpis, U. ;
Kelmere, A. Melbarde ;
Borg, M. ;
Xuereb, D. ;
Ghita, M. C. ;
Noble, M. ;
Kolman, J. ;
Grabljevec, S. ;
Turner, D. ;
Lansbury, L. ;
Grundmann, H. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (02) :398-407
[2]
Dellinger RP, 2008, INTENS CARE MED, V34, P783, DOI [10.1007/s00134-007-0934-2, 10.1007/s00134-008-1040-9, 10.1097/01.CCM.0000298158.12101.41]
[3]
Managing antimicrobial resistance in intensive care units [J].
Gandhi, Tejal N. ;
DePestel, Daryl D. ;
Collins, Curtis D. ;
Nagel, Jerod ;
Washer, Laraine L. .
CRITICAL CARE MEDICINE, 2010, 38 (08) :S315-S323
[4]
Impact of antimicrobial stewardship in critical care: a systematic review [J].
Kaki, Reham ;
Elligsen, Marion ;
Walker, Sandra ;
Simor, Andrew ;
Palmay, Lesley ;
Daneman, Nick .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (06) :1223-1230
[5]
Appraising Contemporary Strategies to Combat Multidrug Resistant Gram-Negative Bacterial Infections-Proceedings and Data From the Gram-Negative Resistance Summit [J].
Kollef, Marin H. ;
Golan, Yoav ;
Micek, Scott T. ;
Shorr, Andrew F. ;
Restrepo, Marcos I. .
CLINICAL INFECTIOUS DISEASES, 2011, 53 :S33-S55
[6]
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock [J].
Kumar, Arland ;
Roberts, Daniel ;
Wood, Kenneth E. ;
Light, Bruce ;
Parrillo, Joseph E. ;
Sharma, Satendra ;
Suppes, Robert ;
Feinstein, Daniel ;
Zanotti, Sergio ;
Taiberg, Leo ;
Gurka, David ;
Kumar, Aseem ;
Cheang, Mary .
CRITICAL CARE MEDICINE, 2006, 34 (06) :1589-1596
[7]
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study [J].
Kumarasamy, Karthikeyan K. ;
Toleman, Mark A. ;
Walsh, Timothy R. ;
Bagaria, Jay ;
Butt, Fafhana ;
Balakrishnan, Ravikumar ;
Chaudhary, Uma ;
Doumith, Michel ;
Giske, Christian G. ;
Irfan, Seema ;
Krishnan, Padma ;
Kumar, Anil V. ;
Maharjan, Sunil ;
Mushtaq, Shazad ;
Noorie, Tabassum ;
Paterson, David L. ;
Pearson, Andrew ;
Perry, Claire ;
Pike, Rachel ;
Rao, Bhargavi ;
Ray, Ujjwayini ;
Sarma, Jayanta B. ;
Sharma, Madhu ;
Sheridan, Elizabeth ;
Thirunarayan, Mandayam A. ;
Turton, Jane ;
Upadhyay, Supriya ;
Warner, Marina ;
Welfare, William ;
Livermore, David M. ;
Woodford, Neil .
LANCET INFECTIOUS DISEASES, 2010, 10 (09) :597-602
[8]
Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007 [J].
Lagu, Tara ;
Rothberg, Michael B. ;
Shieh, Meng-Shiou ;
Pekow, Penelope S. ;
Steingrub, Jay S. ;
Lindenauer, Peter K. .
CRITICAL CARE MEDICINE, 2012, 40 (03) :754-761
[9]
Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study [J].
Lambert, Marie-Laurence ;
Suetens, Carl ;
Savey, Anne ;
Palomar, Mercedes ;
Hiesmayr, Michael ;
Morales, Ingrid ;
Agodi, Antonella ;
Frank, Uwe ;
Mertens, Karl ;
Schumacher, Martin ;
Wolkewitz, Martin .
LANCET INFECTIOUS DISEASES, 2011, 11 (01) :30-38
[10]
An observational study on bloodstream extended-spectrum beta-lactamase infection in critical care unit: Incidence, risk factors and its impact on outcome [J].
Nasa, Prashant ;
Juneja, Deven ;
Singh, Omender ;
Dang, Rohit ;
Singh, Akhilesh .
EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2012, 23 (02) :192-195