Detecting shared pathogenesis from the shared genetics of immune-related diseases

被引：419

作者：

Zhernakova, Alexandra ^{[1
]}

van Diemen, Cleo C. ^{[2
]}

Wijmenga, Cisca ^{[1
,2
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Med Genet, NL-3508 AB Utrecht, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 01期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; INFLAMMATORY-BOWEL-DISEASE; SINGLE-NUCLEOTIDE POLYMORPHISMS; TYPE-1 DIABETES LOCUS; REGULATORY T-CELLS; RHEUMATOID-ARTHRITIS; CELIAC-DISEASE; CROHNS-DISEASE; AUTOIMMUNE-DISEASES;

D O I：

10.1038/nrg2489

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent genetic studies have revealed shared immunological mechanisms in several immune-related disorders that further our understanding of the development and concomitance of these diseases. Our Review focuses on these shared aspects, using the novel findings of recently performed genome-wide association studies and non-synonymous SNP scans as a starting point. We discuss how identifying new genes that are associated with more than one autoimmune or chronic inflammatory disorder could explain the genetic basis of the shared pathogenesis of immune-related diseases. This analysis helps to highlight the key molecular pathways that are involved in these disorders and the potential roles of novel genes in immune-related diseases.

引用

页码：43 / 55

页数：13

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