Peptides, enzymes and obesity: New insights from a 'dead' enzyme

被引：58

作者：

Fricker, LD ^{[1
]}

Leiter, EH

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(99)01448-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The identification of the fat mutation, which causes obesity in mice, as a defect in carboxypeptidase E (CPE) has raised more questions than answers. CPE is required for the processing of numerous neuroendocrine peptides and a mutation that inactivates CPE was predicted to be lethal. However, Cpe(fat) mutated mice live and become obese. So, why are mice with the Cpe(fat) mutation viable, and why does obesity develop as a consequence of the pleiotropic effects of this mutant allele? Recently, several new members of the carboxypeptidase family have been discovered, of which at least one, CPD, can partially compensate by contributing to neuroendocrine pep tide processing. Obesity due to the Cpe(fat) mutation is not caused by increased food consumption but, rather, is a result of defective nutrient partitioning, the exact mechanism of which remains to be elucidated.

引用

页码：390 / 393

页数：4

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