The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome

被引：27

作者：

Corgosinho, Flavia Campos ^{[1
]}

de Piano, Aline ^{[1
]}

Sanches, Priscila L. ^{[1
]}

Campos, Raquel M. ^{[1
]}

Silva, Patricia L. ^{[1
]}

Carnier, June ^{[1
]}

Oyama, Lila M. ^{[1
]}

Tock, Lian ^{[1
]}

Tufik, Sergio ^{[3
]}

de Mello, Marco T. ^{[1
,3
]}

Damaso, Ana R. ^{[1
,2
]}

机构：

[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Paulista Med Sch, BR-11060001 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Post Grad Program Interdisciplinary Hlth Sci, BR-04020050 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Postgrad Program Psychobiol, Paulista Med Sch, BR-04020050 Sao Paulo, Brazil

来源：

INFLAMMATION | 2012年 / 35卷 / 03期

关键词：

PAI-1; interdisciplinary therapy; metabolic syndrome; energy balance; inflammation; adolescents; INSULIN-RESISTANCE; CHILDREN; WEIGHT; NEUROPEPTIDES; DISORDERS; BIOMARKER; LEPTIN;

D O I：

10.1007/s10753-011-9397-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity is a chronic inflammatory disease and is considered a risk factor for metabolic syndrome. In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. The clinical trial registration number is NCT01358773.

引用

页码：944 / 951

页数：8

共 33 条

[1] PAI-1 and the metabolic syndrome - Links, causes, and consequences [J].

Alessi, Marie-Christine ;

Juhan-Vague, Irene .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (10) :2200-2207

[2] Relationships of PAI-1 levels to central obesity and liver steatosis in a sample of adult male population in southern Italy [J].

Barbato, Antonio ;

Iacone, Roberto ;

Tarantino, Giovanni ;

Russo, Ornella ;

Sorrentino, Paolo ;

Avallone, Sonia ;

Galletti, Ferruccio ;

Farinaro, Eduardo ;

Della Valle, Elisabetta ;

Strazzullo, Pasquale .

INTERNAL AND EMERGENCY MEDICINE, 2009, 4 (04) :315-323

[3] Leptin and atherosclerosis [J].

Beltowski, Jerzy .

ATHEROSCLEROSIS, 2006, 189 (01) :47-60

[4] Long-term multidisciplinary therapy decreases predictors and prevalence of metabolic syndrome in obese adolescents [J].

Caranti, Danielle Arisa ;

Tock, Lian ;

Prado, Wagner L. ;

Siqueira, Kali O. ;

de Piano, Aline ;

Lofrano, Mara ;

Damaso, Ana R. ;

Cristofalo, Dejaldo M. J. ;

Lederman, Henrique ;

de Mello, Marco Tulio ;

Tufik, Sergio .

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2007, 17 (06) :E11-E13

[5]

CDC, 2002, NAT CTR HLTH STAT CD

[6] Plasminogen activator inhibitor type 1 (PAI-1) is a valuable biomarker for predicting the metabolic syndrome (MS) in institutionalized elderly residents in Taiwan [J].

Chou, Yin-Yi ;

Sheu, Wayne H-H ;

Tang, Yih-Jing ;

Chen, Yi-Ming ;

Liao, Szu-Chia ;

Chuang, Ya-Wen ;

Lin, Chu-Sheng ;

Chen, Der-Yuan .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2009, 49 :S41-S45

[7]

Coffey C.S., 2011, CARDIOLOGY RES PRACT, V4, P541

[8] Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss [J].

Damaso, Ana R. ;

de Piano, Aline ;

Sanches, Priscila L. ;

Corgosinho, Flavia ;

Tock, Lian ;

Oyama, Lila M. ;

Tock, Luciana ;

Oller do Nascimento, Claudia M. ;

Tufik, Sergio ;

de Mello, Marco Tulio .

PEPTIDES, 2011, 32 (07) :1384-1391

[9] The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents [J].

de Piano, Aline ;

Tock, Lian ;

Carnier, June ;

Foschini, Denis ;

Sanches, Priscila de Lima ;

Correa, Fabiola Alvise ;

Oyama, Lila Missae ;

Oller do Nascimento, Claudia Maria ;

Lederman, Henrique Manoel ;

Ernandes, Regina ;

de Mello, Marco Tulio ;

Tufik, Sergio ;

Damaso, Ana .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2010, 22 (05) :557-563

[10] Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy [J].

de Piano, Aline ;

Tock, Lian ;

Carnier, June ;

Oyama, Lila M. ;

Oller do Nascimento, Claudia M. ;

Martinz, Aniella C. ;

Foschini, Denis ;

Sanches, Priscila L. ;

Ernandes, Regina M. Y. ;

de Mello, Marco Tulio ;

Tufik, Sergio ;

Damaso, Ana R. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2010, 59 (05) :613-619

← 1 2 3 4 →