Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex

被引:276
作者
Hamann, M [1 ]
Rossi, DJ [1 ]
Attwell, D [1 ]
机构
[1] UCL, Dept Physiol, London WC1E 6BT, England
基金
英国惠康基金;
关键词
D O I
10.1016/S0896-6273(02)00593-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We show that information flow through the adult cerebellar cortex, from the mossy fiber input to the Purkinje cell output, is controlled by furosemide-sensitive, diazepam- and neurosteroid-insensitive GABA(A) receptors on granule cells, which are activated both tonically and by GABA spillover from synaptic release sites. Tonic activation of these receptors contributes a 3-fold larger mean inhibitory conductance than GABA released synaptically by high-frequency stimulation. Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum.
引用
收藏
页码:625 / 633
页数:9
相关论文
共 38 条
[1]   NONVESICULAR RELEASE OF NEUROTRANSMITTER [J].
ATTWELL, D ;
BARBOUR, B ;
SZATKOWSKI, M .
NEURON, 1993, 11 (03) :401-407
[2]   SYNAPTIC BACKGROUND ACTIVITY INFLUENCES SPATIOTEMPORAL INTEGRATION IN SINGLE PYRAMIDAL CELLS [J].
BERNANDER, O ;
DOUGLAS, RJ ;
MARTIN, KAC ;
KOCH, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11569-11573
[3]   Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABA(A) receptors [J].
Brickley, SG ;
CullCandy, SG ;
Farrant, M .
JOURNAL OF PHYSIOLOGY-LONDON, 1996, 497 (03) :753-759
[4]   Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance [J].
Brickley, SG ;
Revilla, V ;
Cull-Candy, SG ;
Wisden, W ;
Farrant, M .
NATURE, 2001, 409 (6816) :88-92
[5]   SYNAPTIC EXCITATION OF INDIVIDUAL RAT CEREBELLAR GRANULE CELLS IN-SITU - EVIDENCE FOR THE ROLE OF NMDA RECEPTORS [J].
DANGELO, E ;
DEFILIPPI, G ;
ROSSI, P ;
TAGLIETTI, V .
JOURNAL OF PHYSIOLOGY-LONDON, 1995, 484 (02) :397-413
[6]   Neurosteroid modulation of GABA IPSCs is phosphorylation dependent [J].
Fáncsik, A ;
Linn, DM ;
Tasker, JG .
JOURNAL OF NEUROSCIENCE, 2000, 20 (09) :3067-3075
[7]   SYNAPTIC INTEGRATION IN A MODEL OF CEREBELLAR GRANULE CELLS [J].
GABBIANI, F ;
MIDTGAARD, J ;
KNOPFEL, T .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (02) :999-1009
[8]   Glutamate spillover mediates excitatory transmission in the rat olfactory bulb [J].
Isaacson, JS .
NEURON, 1999, 23 (02) :377-384
[9]  
Jechlinger M, 1998, J NEUROSCI, V18, P2449
[10]   WHOLE-CELL AND SINGLE-CHANNEL CURRENTS ACTIVATED BY GABA AND GLYCINE IN GRANULE CELLS OF THE RAT CEREBELLUM [J].
KANEDA, M ;
FARRANT, M ;
CULLCANDY, SG .
JOURNAL OF PHYSIOLOGY-LONDON, 1995, 485 (02) :419-435