RNA-guided genome editing a la carte

被引：11

作者：

Horvath, Philippe ^{[1
]}

Barrangou, Rodolphe ^{[2
]}

机构：

[1] DuPont Nutr & Hlth, F-86220 Dange St Romain, France

[2] DuPont Nutr & Hlth, Madison, WI 53716 USA

来源：

CELL RESEARCH | 2013年 / 23卷 / 06期

关键词：

IMMUNE-SYSTEM; CRISPR/CAS; DNA; BACTERIA;

D O I：

10.1038/cr.2013.39

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage. © 2013 IBCB, SIBS, CAS All rights reserved.

引用

页码：733 / 734

页数：2

共 10 条

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