Effects of Omeprazole on Plasma Levels of Raltegravir

被引：64

作者：

Iwamoto, Marian ^{[1
]}

Wenning, Larissa A. ^{[1
]}

Nguyen, Bach-Yen ^{[1
]}

Teppler, Hedy ^{[1
]}

Moreau, Allison R. ^{[1
]}

Rhodes, Rand R. ^{[1
]}

Hanley, William D. ^{[1
]}

Jin, Bo ^{[1
]}

Harvey, Charlotte M. ^{[1
]}

Breidinger, Sheila A. ^{[1
]}

Azrolan, Neal ^{[1
]}

Farmer, H. Frank, Jr. ^{[2
]}

Isaacs, Robin D. ^{[1
]}

Chodakewitz, Jeffery A. ^{[1
]}

Stone, Julie A. ^{[1
]}

Wagner, John A. ^{[1
]}

机构：

[1] Merck & Co Inc, Whitehouse Stn, NJ USA

[2] Covance Clin Res Unit, Daytona Beach, FL USA

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 48卷 / 04期

关键词：

D O I：

10.1086/596503

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Raltegravir, a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has pH-dependent solubility. Raltegravir plasma concentration increases with omeprazole coadministration in healthy subjects; this is likely secondary to an increase in bioavailability attributable to increased gastric pH. Increased gastric pH has been reported in HIV-1 infected individuals, and the effects of omeprazole in this intended population may be diminished. Further investigation is necessary.

引用

页码：489 / 492

页数：4

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