Studies on possible protection against snake venom using Mucuna pruriens protein immunization

被引：23

作者：

Aguiyi, JC ^{[1
]}

Igweh, AC

Egesie, UG

Leoncini, R

机构：

[1] Univ Jos, Dept Pharmacol & Clin Pharm, Jos, Nigeria

[2] NITR, Dept Biochem & Therapeut, Vom, Nigeria

[3] Univ Jos, Dept Physiol, Jos, Nigeria

[4] Univ Siena, Ist Biochim & Enzimol, I-53100 Siena, Italy

来源：

FITOTERAPIA | 1999年 / 70卷 / 01期

关键词：

Mucuna pruriens; immunization; cobra venom;

D O I：

10.1016/S0367-326X(98)00004-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Immunization against cobra venom using Mucuna pruriens derived serum immunoglobulins was carried out in a mouse model. The neutralizing ability of circulating antibodies was assessed by challenging the immunized mice with a minimum lethal dose of purified venom after 4, 24, 72 and 168 h. The single injection of the antibody preparation produced a high and sustained immune response with high survival rates of treated animals. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：21 / 24

页数：4

共 7 条

[1]

Aguiyi JC, 1996, W AFR J BIOL SCI, V5, P71

[2]

AGUIYI JC, IN PRESS J BIOTECHNO

[3]

RUSSELL FE, 1991, TOXICOLOGY BASIC SCI, P753

[4]

SOFOWORA A, 1982, MED PLANTS TRADITION, P6