Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus

被引：156

作者：

Fan, Liuping ^{[1
,2
]}

Ding, Shaodong ^{[1
]}

Ai, Lianzhong ^{[2
]}

Deng, Kequan ^{[1
]}

机构：

[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China

[2] Technol Ctr Bright Dairy & Food Co Ltd, State Key Lab Dairy Biotechnol, Shanghai 200436, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Inonotus obliquus; Polysaccharides; Purification; Antitumor; Immunomodulatory; IN-VIVO ANTITUMOR; PURIFICATION; FRACTIONS; TUMORS; VITRO;

D O I：

10.1016/j.carbpol.2012.06.013

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I. obliquus by DEAE-Sepharose CL-6B and Sepharose CL-6B column chromatography. In vivo ISP2a had not only shown antitumor activity, but also could significantly enhance the immune response of tumor-bearing mice. In addition, ISP2a significantly enhanced the lymphocyte proliferation and increased the production of TNF-alpha. Results of these studies demonstrated that ISP2a had a potential application as natural antitumor agent with immunomodulatory activity. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：870 / 874

页数：5

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