Hollow-Channel Paper Analytical Devices

被引：149

作者：

Renault, Christophe ^{[1
]}

Li, Xiang ^{[1
]}

Fosdick, Stephen E. ^{[1
]}

Crooks, Richard M. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Ctr Nano & Mol Sci & Technol, Austin, TX 78712 USA

来源：

ANALYTICAL CHEMISTRY | 2013年 / 85卷 / 16期

关键词：

ELECTROCHEMICAL DETECTION; MICROFLUIDIC DEVICES; WAX;

D O I：

10.1021/ac401786h

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We present a microfluidic paper analytical device (PAD) that relies on flow in hollow channels, rather than through a cellulose network, to transport fluids. The flow rate in hollow channels is 7 times higher than in regular paper channels and can be conveniently controlled from 0 to several mm/s by balancing capillary and pressure forces. More importantly, the pressure of a single drop of liquid (similar to 0.2 mbar) is sufficient to induce fast pressure-driven flow, making hollow channels suitable for point of care diagnostics. We demonstrate their utility for simple colorimetric glucose and BSA assays in which the time for liquid transport is reduced by a factor of 4 compared to normal cellulose channels.

引用

页码：7976 / 7979

页数：4

共 25 条

[1] Paper Microzone Plates [J].

Carrilho, Emanuel ;

Phillips, Scott T. ;

Vella, Sarah J. ;

Martinez, Andres W. ;

Whitesides, George M. .

ANALYTICAL CHEMISTRY, 2009, 81 (15) :5990-5998

[2] Understanding Wax Printing: A Simple Micropatterning Process for Paper-Based Microfluidics [J].

Carrilho, Emanuel ;

Martinez, Andres W. ;

Whitesides, George M. .

ANALYTICAL CHEMISTRY, 2009, 81 (16) :7091-7095

[3] "Flow Valve" Microfluidic Devices for Simple, Detectorless, and Label-Free Analyte Quantitation [J].

Chatterjee, Debolina ;

Mansfield, Danielle S. ;

Anderson, Neil G. ;

Subedi, Sudeep ;

Woolley, Adam T. .

ANALYTICAL CHEMISTRY, 2012, 84 (16) :7057-7063

[4]

Davies R. J., 2008, HDB BIOSENSORS BIOCH

[5] SlipChip [J].

Du, Wenbin ;

Li, Liang ;

Nichols, Kevin P. ;

Ismagilov, Rustem F. .

LAB ON A CHIP, 2009, 9 (16) :2286-2292

[6] Use of multiple colorimetric indicators for paper-based microfluidic devices [J].

Dungchai, Wijitar ;

Chailapakul, Orawon ;

Henry, Charles S. .

ANALYTICA CHIMICA ACTA, 2010, 674 (02) :227-233

[7] Electrochemical Detection for Paper-Based Microfluidics [J].

Dungchai, Wijitar ;

Chailapakul, Orawon ;

Henry, Charles S. .

ANALYTICAL CHEMISTRY, 2009, 81 (14) :5821-5826

[8] Controlled reagent transport in disposable 2D paper networks [J].

Fu, Elain ;

Lutz, Barry ;

Kauffman, Peter ;

Yager, Paul .

LAB ON A CHIP, 2010, 10 (07) :918-920

[9]

Glavan A. C., 2013, LAB CHIP

[10] Point of Care Diagnostics: Status and Future [J].

Gubala, Vladimir ;

Harris, Leanne F. ;

Ricco, Antonio J. ;

Tan, Ming X. ;

Williams, David E. .

ANALYTICAL CHEMISTRY, 2012, 84 (02) :487-515

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