The morphology of the immature HIV-1 virion

被引:13
作者
Ohagen, A
Luftig, RB
Reicin, AS
Yin, L
Ikuta, K
Kimura, T
Goff, SP
Hoglund, S
机构
[1] LOUISIANA STATE UNIV,MED CTR,NEW ORLEANS,LA 70112
[2] COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10032
[3] HOKKAIDO UNIV,INST IMMUNOL SCI,SECT SEROL,SAPPORO,HOKKAIDO 060,JAPAN
[4] COLUMBIA UNIV,COLL PHYS & SURG,HOWARD HUGHES MED INST,NEW YORK,NY 10032
[5] COLUMBIA UNIV,COLL PHYS & SURG,DEPT BIOCHEM & BIOPHYS,NEW YORK,NY 10032
关键词
D O I
10.1006/viro.1996.8362
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Newly released HIV-1 particles exhibit an immature morphology, previously reported to be characterized by a doughnut/ring-shaped structure. In this study we showed that among immature extracellular virus particles not only were particles with doughnut-shaped morphology present, but particles with a crescent morphology were also observed. These particles occurred with different frequencies, depending on whether they were in the cell or in cell-free fractions. The crescent-shaped particles were more abundant in the cell-free fractions, whereas the particles in the cell fraction mainly exhibited doughnut-shaped morphology. The crescent-shaped structure may represent an assembly intermediate. (C) 1997 Academic Press.
引用
收藏
页码:112 / 114
页数:3
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