Activities of newer quinolones against Escherichia coli and Klebsiella pneumoniae containing the plasmid-mediated quinolone resistance determinant qnr

被引：32

作者：

Wang, MG

Sahm, DF

Jacoby, GA

Zhang, YY

Hooper, DC

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[2] Fudan Univ, Huashan Hosp, Inst Antibiot, Shanghai 200040, Peoples R China

[3] Focus Technol, Herndon, VA 20171 USA

[4] Lahey Clin Fdn, Dept Infect Dis, Burlington, MA 01805 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 04期

关键词：

D O I：

10.1128/AAC.48.4.1400-1401.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Seventeen qnr-containing transconjugants were constructed with azide-resistant Escherichia coli J53 as the recipient, and the MICs of 12 quinolones were tested by agar dilution methods. Sitafloxacin, BAYy3118, and premafloxacin had higher activity in vitro than ciprofloxacin against transconjugants and donors containing qnr. The donors had higher quinolone MICs than the transconjugants.

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页码：1400 / 1401

页数：2

相关论文

共 11 条

[1] Mechanisms of action and resistance of older and newer fluoroquinolones [J].

Hooper, DC .

CLINICAL INFECTIOUS DISEASES, 2000, 31 :S24-S28

[2] Activity of and resistance to moxifloxacin in Staphylococcus aureus [J].

Ince, D ;

Zhang, XM ;

Hooper, DC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (04) :1410-1415

[3] Dual targeting of DNA gyrase and topoisomerase IV: Target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone [J].

Ince, D ;

Zhang, XM ;

Silver, LC ;

Hooper, DC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (11) :3370-3380

[4] Prevalence of plasmid-mediated quinolone resistance [J].

Jacoby, GA ;

Chow, N ;

Waites, KB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (02) :559-562

[5] Quinolone resistance from a transferable plasmid [J].

Martínez-Martínez, L ;

Pascual, A ;

Jacoby, GA .

LANCET, 1998, 351 (9105) :797-799

[6] Interaction of plasmid and host quinolone resistance [J].

Martínez-Martínez, L ;

Pascual, A ;

García, I ;

Tran, J ;

Jacoby, GA .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (04) :1037-1039

[7]

National Center for Health Statistics, 2003, M7A6 NAT COMM CLIN L, P1

[8] Activities of new fluoroquinolones against fluoroquinolone-resistant pathogens of the lower respiratory tract [J].

Piddock, LJV ;

Johnson, M ;

Ricci, V ;

Hill, SL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (11) :2956-2960

[9] Detection of the plasmid-mediated quinolone resistance determinant qnr among clinical isolates of Klebsiella pneumoniae producing AmpC-type β-lactamase [J].

Rodríguez-Martínez, JM ;

Pascual, A ;

García, I ;

Martínez-Martínez, L .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (04) :703-706

[10] Mechanism of plasmid-mediated quinolone resistance [J].

Tran, JH ;

Jacoby, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5638-5642