Identification and stereochemistry of the product of 4-HPPD catalyzed oxidation of the ketoacid of methionine

被引:9
作者
Adlington, RM
Baldwin, JE
Crouch, NP
Lee, MH
MacKinnon, CH
机构
[1] DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND
[2] OXFORD CTR MOL SCI,OXFORD OX1 3QY,ENGLAND
关键词
D O I
10.1016/0960-894X(96)00362-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
4-Hydroxyphenylpyruvate dioxygenase catalyzes the conversion of 2-oxo-5-thiahexanoic acid 1, the ketoacid from methionine (Scheme 1) to an unequal mixture of 4-thiapentanoic acid-4-oxide enantiomers 2a. Copyright (C) 1996 Elsevier Science Ltd.
引用
收藏
页码:2003 / 2006
页数:4
相关论文
共 7 条
  • [1] 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE APPEARS TO DISPLAY ALPHA-KETOISOCAPROATE DIOXYGENASE ACTIVITY IN RAT-LIVER
    BALDWIN, JE
    CROUCH, NP
    FUJISHIMA, Y
    LEE, MH
    MACKINNON, CH
    PITT, JPN
    WILLIS, AC
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (12) : 1255 - 1260
  • [2] BALDWIN JE, 1996, BIOORG MED CHEM LETT, V6, P1503
  • [3] A CONVENIENT FAMILY OF CHIRAL SHIFT-REAGENTS FOR MEASUREMENT OF ENANTIOMERIC EXCESSES OF SULFOXIDES
    DESHMUKH, M
    DUNACH, E
    JUGE, S
    KAGAN, HB
    [J]. TETRAHEDRON LETTERS, 1984, 25 (32) : 3467 - 3470
  • [4] DOI JT, 1986, J ORG CHEM, V51, P1026, DOI 10.1021/jo00357a015
  • [5] DUNACH E, 1985, NOUV J CHIM, V9, P1
  • [6] ALTERNATE SUBSTRATES AND INHIBITORS OF BACTERIAL 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE
    PASCAL, RA
    OLIVER, MA
    CHEN, YCJ
    [J]. BIOCHEMISTRY, 1985, 24 (13) : 3158 - 3165
  • [7] SABOURIN PJ, 1982, J BIOL CHEM, V257, P7460