The Role of the Immune Cells in Fracture Healing

被引：219

作者：

Baht, Gurpreet S. ^{[1
,2
,3
]}

Vi, Linda ^{[4
]}

Alman, Benjamin A. ^{[1
,3
]}

机构：

[1] Duke Univ, Duke Mol Physiol Inst, Dept Orthopaed Surg, DUMC 104775,300 North Duke St, Durham, NC 27701 USA

[2] Duke Mol Physiol Inst, Durham, NC 27701 USA

[3] Duke Univ, Dept Orthopaed Surg, 200 Trent Dr,Orange Zone 5th floor, Durham, NC 27710 USA

[4] Univ Toronto, Toronto, ON, Canada

来源：

CURRENT OSTEOPOROSIS REPORTS | 2018年 / 16卷 / 02期

关键词：

D O I：

10.1007/s11914-018-0423-2

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Purpose of review Bone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of hematopoietic and mesenchymal cells. Within this review we will discuss the functional role of immune cells as it pertains to bone fracture healing. In doing so, we will outline the cytokines secreted and their effects within the healing fracture callus. Recent findings Macrophages have been found to play an important role in fracture healing. These immune cells signal to other cells of the fracture callus, modulating bone healing. Summary Cytokines and cellular signals within fracture healing continue to be studied. The findings from this work have helped to reinforce the importance of osteoimmunity in bone fracture healing. Owing to these efforts, immunomodulation is emerging as a potential therapeutic target to improve bone fracture healing.

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页码：138 / 145

页数：8

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