Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: Role of CD4(+) T cells in controlling larval development

被引：74

作者：

AlQaoud, KM

Taubert, A

Zahner, H

Fleischer, B

Hoerauf, A

机构：

[1] UNIV GIESSEN,INST PARASITOL,GIESSEN,GERMANY

[2] BERNHARD NOCHT INST TROP MED,DEPT IMMUNOL & MED MICROBIOL,HAMBURG,GERMANY

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 06期

关键词：

D O I：

10.1128/IAI.65.6.2457-2461.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Litomosoides sigmodontis is the only filaria which develops from infective larvae into adults in immunocompetent laboratory mice. Depletion of CD4(+) T cells from infected BALB/c mice resulted in worm and microfilarial burdens significantly higher than those of infected controls. Th2 cytokines, eosinophilia, and immunoglobulin E, which were strongly induced in infected controls, were diminished in CD4-depleted mice.

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页码：2457 / 2461

页数：5

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