yMGV: helping biologists with yeast microarray data mining

被引:18
作者
Le Crom, S [1 ]
Devaux, F [1 ]
Jacq, C [1 ]
Marc, P [1 ]
机构
[1] Ecole Normale Super, CNRS, UMR8541, Genet Mol Lab, F-75005 Paris, France
关键词
D O I
10.1093/nar/30.1.76
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
yMGV (yeast Microarray Global Viewer) was designed to provide biologists with meaningful information from genome-wide yeast expression data. The database includes most of the available expression data published on yeast microarrays over the last 4 years. It provides customizable tools for the rapid visualization of expression profiles associated with a set of genes from all published experiments. It also allows users to compare the results from different publications so that they can identify genes with common expression profiles. We used yMGV to perform global analyses to find a gene expression profile specific for given biological conditions and to locate functional gene clusters on chromosomes. Other organisms will be added to this database. yMGV is accessible on the web at http://transcriptome.ens.fr/ymgv.
引用
收藏
页码:76 / 79
页数:4
相关论文
共 19 条
[1]   Systematic management and analysis of yeast gene expression data [J].
Aach, J ;
Rindone, W ;
Church, GM .
GENOME RESEARCH, 2000, 10 (04) :431-445
[2]   Saccharomyces Genome Database provides tools to survey gene expression and functional analysis data [J].
Ball, CA ;
Jin, H ;
Sherlock, G ;
Weng, S ;
Matese, JC ;
Andrada, R ;
Binkley, G ;
Dolinski, K ;
Dwight, SS ;
Harris, MA ;
Issel-Tarver, L ;
Schroeder, R ;
Botstein, D ;
Cherry, JM .
NUCLEIC ACIDS RESEARCH, 2001, 29 (01) :80-81
[3]   Genomewide studies of histone deacetylase function in yeast [J].
Bernstein, BE ;
Tong, JK ;
Schreiber, SL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (25) :13708-13713
[4]   Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation [J].
Bone, JR ;
Roth, SY .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (03) :1808-1813
[5]   YPD™, PombePD™ and WormPD™:: model organism volumes of the BioKnowledge™ Library, an integrated resource for protein information [J].
Costanzo, MC ;
Crawford, ME ;
Hirschman, JE ;
Kranz, JE ;
Olsen, P ;
Robertson, LS ;
Skrzypek, MS ;
Braun, BR ;
Hopkins, KL ;
Kondu, P ;
Lengieza, C ;
Lew-Smith, JE ;
Tillberg, M ;
Garrels, JI .
NUCLEIC ACIDS RESEARCH, 2001, 29 (01) :75-79
[6]   Exploring the metabolic and genetic control of gene expression on a genomic scale [J].
DeRisi, JL ;
Iyer, VR ;
Brown, PO .
SCIENCE, 1997, 278 (5338) :680-686
[7]   Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO) [J].
Dwight, SS ;
Harris, MA ;
Dolinski, K ;
Ball, CA ;
Binkley, G ;
Christie, KR ;
Fisk, DG ;
Issel-Tarver, L ;
Schroeder, M ;
Sherlock, G ;
Sethuraman, A ;
Weng, S ;
Botstein, D ;
Cherry, JM .
NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :69-72
[8]   Mitochondrial control of iron homeostasis - A genome wide analysis of gene expression in a yeast frataxin-deficient strain [J].
Foury, F ;
Talibi, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) :7762-7768
[9]   Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae [J].
Hallstrom, TC ;
Moye-Rowley, WS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) :37347-37356
[10]   Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating [J].
Heiman, MG ;
Walter, P .
JOURNAL OF CELL BIOLOGY, 2000, 151 (03) :719-730