Toll-like receptors: key mediators of microbe detection

被引：550

作者：

Underhill, DM ^{[1
]}

Ozinsky, A ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98105 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(01)00304-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors are pattern-recognition receptors that have key roles in detecting microbes and initiating inflammatory responses, Recently, a host of new microbial products that activate specific Toll-like receptors have been defined, and additional components that mediate intracellular signaling have been identified. There has also been greater recognition of the importance of specific Toll-like receptors in host defense.

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页码：103 / 110

页数：8

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