Antimelanogenic activity of 3,4-dihydroxyacetophenone: Inhibition of tyrosinase and MITF

被引：42

作者：

Kim, YJ

No, JK

Lee, JS

Kim, MS

Chung, HY ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Aging Tissue Bank, Pusan 609735, South Korea

[2] Pusan Womens Coll, Dept Cosmetol, Pusan 617734, South Korea

[3] Pusan Natl Univ, Dept Nursing, Pusan 609735, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 02期

关键词：

antimelanogenic activity; 3,4-dihydroxyacetophenone; melanin; microphthalmia transcription factor; tyrosinase;

D O I：

10.1271/bbb.70.532

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

3,4-Dihydroxyacetophenone (3,4-DHAP) was evaluated for antimelanogenic activity. The tyrosinase inhibitory action by 3,4-DHAP using mushroom tyrosinase revealed a strong inhibitory effect. To further explore this matter, inhibition of tyrosinase and melanin content was measured in B16 melanoma cells (B16 cells). Further, tyrosinase and microphthalmia transcription factor (MITF) protein levels were determined by the Western blot method. Additionally, tyrosinase and MITF protein levels were reduced by 3,4-DHAP. Our data indicate that the antimelanogenic activity of 3,4-DHAP was probably due to its inhibition of tyrosinase activity and the suppression of tyrosinase and MITF protein levels.

引用

页码：532 / 534

页数：3

共 12 条

[1]

BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes [J].