Radiotherapy and antiangiogenic TM in lung cancer

被引:87
作者
Khan, MK
Miller, MW
Taylor, J
Gill, NK
Dick, RD
Van Golen, K
Brewer, GJ
Merajver, SD
机构
[1] Univ Michigan, Med Ctr, Comprehens Canc & Geriat Ctr, Dept Radiat Oncol,Div Radiat & Canc Biol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Med Ctr, Dept Stat, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Med Ctr, Dept Human Genet, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Med Ctr, Dept Internal Med Med Oncol, Ann Arbor, MI 48109 USA
来源
NEOPLASIA | 2002年 / 4卷 / 02期
关键词
angiogenesis; radiation; cancer; lung; copper;
D O I
10.1038/sj.neo.7900218
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tetrathiomolybdate (TM) is a potent nontoxic orally delivered copper complexing agent under development for the last several years for the treatment of Wilson's disease. It has been shown to block angiogenesis in primary and metastatic tumors. Therefore, the combination of cytotoxic radiotherapy (RT) and antiangio-genic TM could target both the existing tumor and the tumor microvasculature in a comprehensive strategy. Using a Lewis lung high metastatic (LLHM) carcinoma mouse tumor model, we demonstrate that the combination of TM and RT is more effective than either used as monotherapy. We also show that their therapeutic effects are additive, with no additional toxicity. We show that TM has no significant cytotoxicity in vitro against LLHM tumor cells, further supporting the antiangiogenic mechanism for its action.
引用
收藏
页码:164 / 170
页数:7
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