共 29 条
Role of VP2 amino acid 141 in tropism of Theiler's virus within the central nervous system
被引:14
作者:

Jarousse, N
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE

Martinat, C
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE

Syan, S
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE

Brahic, M
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE

McAllister, A
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE
机构:
[1] INST PASTEUR,CNRS,URA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE
关键词:
D O I:
10.1128/JVI.70.11.8213-8217.1996
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Following intracranial inoculation, Theiler's virus causes either an acute encephalitis (strain GDVII) or a chronic demyelinating disease (strain DA). The DA strain sequentially infects the grey matter of the brain, the grey matter of the spinal cord, and, finally, the white matter of the spinal cord, where it persists in glial cells and causes demyelinating lesions. Analysis of the phenotype of recombinant viruses has shown that the viral capsid contains determinants for persistence and demyelination. Our previous studies showed that a Lys at position 141 of the VP2 capsid protein (VP2-141) could render a chimeric virus persistent. We also reported that another recombinant virus, virus R5, migrated from the grey matter of the brain to that of the spinal cord inefficiently and was unable to infect the white matter of the spinal cord. In this article, we report that introducing a Lys at position VP2-141 in virus R5 increases its ability to infect the white matter of the spinal cord. Our results indicate that this amino acid is important for the spread of the virus within the central nervous system.
引用
收藏
页码:8213 / 8217
页数:5
相关论文
共 29 条
- [1] IDENTIFICATION OF THEILERS VIRUS-INFECTED CELLS IN THE CENTRAL-NERVOUS-SYSTEM OF THE MOUSE DURING DEMYELINATING DISEASE[J]. MICROBIAL PATHOGENESIS, 1987, 3 (05) : 319 - 326AUBERT, C论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,DEPT VIROL,CNRS,UA 041157,F-75724 PARIS 15,FRANCE INST PASTEUR,DEPT VIROL,CNRS,UA 041157,F-75724 PARIS 15,FRANCECHAMORRO, M论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,DEPT VIROL,CNRS,UA 041157,F-75724 PARIS 15,FRANCE INST PASTEUR,DEPT VIROL,CNRS,UA 041157,F-75724 PARIS 15,FRANCEBRAHIC, M论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,DEPT VIROL,CNRS,UA 041157,F-75724 PARIS 15,FRANCE INST PASTEUR,DEPT VIROL,CNRS,UA 041157,F-75724 PARIS 15,FRANCE
- [2] THE INTERACTION OF 2 GROUPS OF MURINE GENES DETERMINES THE PERSISTENCE OF THEILERS VIRUS IN THE CENTRAL-NERVOUS-SYSTEM[J]. JOURNAL OF VIROLOGY, 1992, 66 (08) : 4698 - 4704BUREAU, JF论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,UNITE GENET MAMMIFERES,F-75724 PARIS 15,FRANCEMONTAGUTELLI, X论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,UNITE GENET MAMMIFERES,F-75724 PARIS 15,FRANCELEFEBVRE, S论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,UNITE GENET MAMMIFERES,F-75724 PARIS 15,FRANCEGUENET, JL论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,UNITE GENET MAMMIFERES,F-75724 PARIS 15,FRANCEPLA, M论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,UNITE GENET MAMMIFERES,F-75724 PARIS 15,FRANCEBRAHIC, M论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,UNITE GENET MAMMIFERES,F-75724 PARIS 15,FRANCE
- [3] GENOMIC REGIONS OF NEUROVIRULENCE AND ATTENUATION IN THEILER MURINE ENCEPHALOMYELITIS VIRUS[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (03) : 978 - 982CALENOFF, MA论文数: 0 引用数: 0 h-index: 0机构: NORTHWESTERN UNIV,SCH MED,DEPT NEUROL,CHICAGO,IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT NEUROL,CHICAGO,IL 60611FAABERG, KS论文数: 0 引用数: 0 h-index: 0机构: NORTHWESTERN UNIV,SCH MED,DEPT NEUROL,CHICAGO,IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT NEUROL,CHICAGO,IL 60611LIPTON, HL论文数: 0 引用数: 0 h-index: 0机构: NORTHWESTERN UNIV,SCH MED,DEPT NEUROL,CHICAGO,IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT NEUROL,CHICAGO,IL 60611
- [4] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION[J]. ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) : 156 - 159CHOMCZYNSKI, P论文数: 0 引用数: 0 h-index: 0机构: NCI,MOLEC ONCOL LAB,FREDERICK,MD 21701SACCHI, N论文数: 0 引用数: 0 h-index: 0机构: NCI,MOLEC ONCOL LAB,FREDERICK,MD 21701
- [5] NEUROVIRULENCE DETERMINANTS OF GENETICALLY ENGINEERED THEILER VIRUSES[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) : 4125 - 4129FU, JL论文数: 0 引用数: 0 h-index: 0机构: UNIV CHICAGO,MED CTR,DEPT NEUROL,CHICAGO,IL 60637STEIN, S论文数: 0 引用数: 0 h-index: 0机构: UNIV CHICAGO,MED CTR,DEPT NEUROL,CHICAGO,IL 60637ROSENSTEIN, L论文数: 0 引用数: 0 h-index: 0机构: UNIV CHICAGO,MED CTR,DEPT NEUROL,CHICAGO,IL 60637BODWELL, T论文数: 0 引用数: 0 h-index: 0机构: UNIV CHICAGO,MED CTR,DEPT NEUROL,CHICAGO,IL 60637ROUTBORT, M论文数: 0 引用数: 0 h-index: 0机构: UNIV CHICAGO,MED CTR,DEPT NEUROL,CHICAGO,IL 60637SEMLER, BL论文数: 0 引用数: 0 h-index: 0机构: UNIV CHICAGO,MED CTR,DEPT NEUROL,CHICAGO,IL 60637ROOS, RP论文数: 0 引用数: 0 h-index: 0机构: UNIV CHICAGO,MED CTR,DEPT NEUROL,CHICAGO,IL 60637
- [6] 3-DIMENSIONAL STRUCTURE OF THEILER VIRUS[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) : 2061 - 2065GRANT, RA论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USAFILMAN, DJ论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USAFUJINAMI, RS论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USAICENOGLE, JP论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USAHOGLE, JM论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
- [7] CHIMERIC THEILERS VIRUS WITH ALTERED TROPISM FOR THE CENTRAL-NERVOUS-SYSTEM[J]. JOURNAL OF VIROLOGY, 1994, 68 (05) : 2781 - 2786JAROUSSE, N论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEFIETTE, L论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEGRANT, RA论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEHOGLE, JM论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEMCALLISTER, A论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEMICHIELS, T论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEAUBERT, C论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCETANGY, F论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEBRAHIC, M论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEROSSI, CP论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE
- [8] A SINGLE AMINO-ACID CHANGE DETERMINES PERSISTENCE OF A CHIMERIC THEILERS VIRUS[J]. JOURNAL OF VIROLOGY, 1994, 68 (05) : 3364 - 3368JAROUSSE, N论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEGRANT, RA论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEHOGLE, JM论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEZHANG, L论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCESENKOWSKI, A论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEROOS, RP论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEMICHIELS, T论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEBRAHIC, M论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCEMCALLISTER, A论文数: 0 引用数: 0 h-index: 0机构: INST PASTEUR,CNRS,UA 1157,UNITE VIRUS LENTS,F-75724 PARIS 15,FRANCE
- [9] THE PREDOMINANT VIRUS-ANTIGEN BURDEN IS PRESENT IN MACROPHAGES IN THEILERS MURINE ENCEPHALOMYELITIS VIRUS-INDUCED DEMYELINATING DISEASE[J]. JOURNAL OF VIROLOGY, 1995, 69 (04) : 2525 - 2533LIPTON, HL论文数: 0 引用数: 0 h-index: 0机构: NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60201 NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60201TWADDLE, G论文数: 0 引用数: 0 h-index: 0机构: NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60201 NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60201JELACHICH, ML论文数: 0 引用数: 0 h-index: 0机构: NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60201 NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60201
- [10] THEILERS VIRUS-INFECTION IN MICE - UNUSUAL BIPHASIC DISEASE PROCESS LEADING TO DEMYELINATION[J]. INFECTION AND IMMUNITY, 1975, 11 (05) : 1147 - 1155LIPTON, HL论文数: 0 引用数: 0 h-index: 0机构: NORTHWESTERN UNIV,MED SCH,DEPT NEUROL,CHICAGO,IL 60611 NORTHWESTERN UNIV,MED SCH,DEPT NEUROL,CHICAGO,IL 60611